Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia

Yung Li Yang, Chih Cheng Hsiao, Hsuan Yu Chen, Kai Hsin Lin, Shiann Tarng Jou, Jiann Shiuh Chen, Te Kau Chang, Jiunn Ming Sheen, Sung Liang Yu, Meng Yao Lu, Chao Neng Cheng, Kang Hsi Wu, Shih Chung Wang, Jiaan Der Wang, Hsiu Hao Chang, Shu Rung Lin, Shu Wha Lin, Dong Tsamn Lin

研究成果: Article

9 引文 (Scopus)

摘要

Background: The absence of biallelic TCRγ deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T-cell acute lymphoblastic leukemia (ALL). This study aimed to investigate its prognostic value in Taiwanese patients with T-cell ALL. Procedure: Forty-five children with T-cell ALL were enrolled from six medical centers in Taiwan. Quantitative DNA polymerase chain reaction (Q-PCR) was performed to check the status of TCRγ deletion. The threshold for homozygous deletions by Q-PCR was defined as a fold-change <0.35. Results: ABD was found in 20 patients [20:45] who had higher incidences of induction failure than those without ABD (P=0.03; hazard ratio [HR]=8.13; 95% confidence interval [95% CI]=1.23-53.77) after multivariate regression analysis. Patents with ABD also had inferior EFS and OS (P=0.071 and 0.0196, respectively). Multivariate Cox analysis indicated that the association between ABD and overall survival was independent of age and leukocyte count on presentation (P=0.036; HR=4.25; 95% CI=1.10-16.42). Conclusions: The absence of TCRγ deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T-cell ALL in Taiwan. Providing patients with T-cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials.

原文English
頁(從 - 到)846-851
頁數6
期刊Pediatric Blood and Cancer
58
發行號6
DOIs
出版狀態Published - 2012 六月 1

指紋

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
DNA-Directed DNA Polymerase
Taiwan
Multivariate Analysis
V(D)J Recombination
Confidence Intervals
Polymerase Chain Reaction
Induction Chemotherapy
Patents
Thymocytes
Treatment Failure
Leukocyte Count
Regression Analysis
Clinical Trials
Pediatrics
Survival
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

引用此文

Yang, Yung Li ; Hsiao, Chih Cheng ; Chen, Hsuan Yu ; Lin, Kai Hsin ; Jou, Shiann Tarng ; Chen, Jiann Shiuh ; Chang, Te Kau ; Sheen, Jiunn Ming ; Yu, Sung Liang ; Lu, Meng Yao ; Cheng, Chao Neng ; Wu, Kang Hsi ; Wang, Shih Chung ; Wang, Jiaan Der ; Chang, Hsiu Hao ; Lin, Shu Rung ; Lin, Shu Wha ; Lin, Dong Tsamn. / Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia. 於: Pediatric Blood and Cancer. 2012 ; 卷 58, 編號 6. 頁 846-851.
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title = "Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia",
abstract = "Background: The absence of biallelic TCRγ deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T-cell acute lymphoblastic leukemia (ALL). This study aimed to investigate its prognostic value in Taiwanese patients with T-cell ALL. Procedure: Forty-five children with T-cell ALL were enrolled from six medical centers in Taiwan. Quantitative DNA polymerase chain reaction (Q-PCR) was performed to check the status of TCRγ deletion. The threshold for homozygous deletions by Q-PCR was defined as a fold-change <0.35. Results: ABD was found in 20 patients [20:45] who had higher incidences of induction failure than those without ABD (P=0.03; hazard ratio [HR]=8.13; 95{\%} confidence interval [95{\%} CI]=1.23-53.77) after multivariate regression analysis. Patents with ABD also had inferior EFS and OS (P=0.071 and 0.0196, respectively). Multivariate Cox analysis indicated that the association between ABD and overall survival was independent of age and leukocyte count on presentation (P=0.036; HR=4.25; 95{\%} CI=1.10-16.42). Conclusions: The absence of TCRγ deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T-cell ALL in Taiwan. Providing patients with T-cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials.",
author = "Yang, {Yung Li} and Hsiao, {Chih Cheng} and Chen, {Hsuan Yu} and Lin, {Kai Hsin} and Jou, {Shiann Tarng} and Chen, {Jiann Shiuh} and Chang, {Te Kau} and Sheen, {Jiunn Ming} and Yu, {Sung Liang} and Lu, {Meng Yao} and Cheng, {Chao Neng} and Wu, {Kang Hsi} and Wang, {Shih Chung} and Wang, {Jiaan Der} and Chang, {Hsiu Hao} and Lin, {Shu Rung} and Lin, {Shu Wha} and Lin, {Dong Tsamn}",
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Yang, YL, Hsiao, CC, Chen, HY, Lin, KH, Jou, ST, Chen, JS, Chang, TK, Sheen, JM, Yu, SL, Lu, MY, Cheng, CN, Wu, KH, Wang, SC, Wang, JD, Chang, HH, Lin, SR, Lin, SW & Lin, DT 2012, 'Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia', Pediatric Blood and Cancer, 卷 58, 編號 6, 頁 846-851. https://doi.org/10.1002/pbc.24021

Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia. / Yang, Yung Li; Hsiao, Chih Cheng; Chen, Hsuan Yu; Lin, Kai Hsin; Jou, Shiann Tarng; Chen, Jiann Shiuh; Chang, Te Kau; Sheen, Jiunn Ming; Yu, Sung Liang; Lu, Meng Yao; Cheng, Chao Neng; Wu, Kang Hsi; Wang, Shih Chung; Wang, Jiaan Der; Chang, Hsiu Hao; Lin, Shu Rung; Lin, Shu Wha; Lin, Dong Tsamn.

於: Pediatric Blood and Cancer, 卷 58, 編號 6, 01.06.2012, p. 846-851.

研究成果: Article

TY - JOUR

T1 - Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia

AU - Yang, Yung Li

AU - Hsiao, Chih Cheng

AU - Chen, Hsuan Yu

AU - Lin, Kai Hsin

AU - Jou, Shiann Tarng

AU - Chen, Jiann Shiuh

AU - Chang, Te Kau

AU - Sheen, Jiunn Ming

AU - Yu, Sung Liang

AU - Lu, Meng Yao

AU - Cheng, Chao Neng

AU - Wu, Kang Hsi

AU - Wang, Shih Chung

AU - Wang, Jiaan Der

AU - Chang, Hsiu Hao

AU - Lin, Shu Rung

AU - Lin, Shu Wha

AU - Lin, Dong Tsamn

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Background: The absence of biallelic TCRγ deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T-cell acute lymphoblastic leukemia (ALL). This study aimed to investigate its prognostic value in Taiwanese patients with T-cell ALL. Procedure: Forty-five children with T-cell ALL were enrolled from six medical centers in Taiwan. Quantitative DNA polymerase chain reaction (Q-PCR) was performed to check the status of TCRγ deletion. The threshold for homozygous deletions by Q-PCR was defined as a fold-change <0.35. Results: ABD was found in 20 patients [20:45] who had higher incidences of induction failure than those without ABD (P=0.03; hazard ratio [HR]=8.13; 95% confidence interval [95% CI]=1.23-53.77) after multivariate regression analysis. Patents with ABD also had inferior EFS and OS (P=0.071 and 0.0196, respectively). Multivariate Cox analysis indicated that the association between ABD and overall survival was independent of age and leukocyte count on presentation (P=0.036; HR=4.25; 95% CI=1.10-16.42). Conclusions: The absence of TCRγ deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T-cell ALL in Taiwan. Providing patients with T-cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials.

AB - Background: The absence of biallelic TCRγ deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T-cell acute lymphoblastic leukemia (ALL). This study aimed to investigate its prognostic value in Taiwanese patients with T-cell ALL. Procedure: Forty-five children with T-cell ALL were enrolled from six medical centers in Taiwan. Quantitative DNA polymerase chain reaction (Q-PCR) was performed to check the status of TCRγ deletion. The threshold for homozygous deletions by Q-PCR was defined as a fold-change <0.35. Results: ABD was found in 20 patients [20:45] who had higher incidences of induction failure than those without ABD (P=0.03; hazard ratio [HR]=8.13; 95% confidence interval [95% CI]=1.23-53.77) after multivariate regression analysis. Patents with ABD also had inferior EFS and OS (P=0.071 and 0.0196, respectively). Multivariate Cox analysis indicated that the association between ABD and overall survival was independent of age and leukocyte count on presentation (P=0.036; HR=4.25; 95% CI=1.10-16.42). Conclusions: The absence of TCRγ deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T-cell ALL in Taiwan. Providing patients with T-cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials.

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U2 - 10.1002/pbc.24021

DO - 10.1002/pbc.24021

M3 - Article

C2 - 22180181

AN - SCOPUS:84863353013

VL - 58

SP - 846

EP - 851

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 6

ER -