Absence of gender effect on children with attention-deficit/hyperactivity disorder as assessed by optimized voxel-based morphometry

Pinchen Yang, Pei Ning Wang, Kai Hsiang Chuang, Yuh Jyh Jong, Tzu Cheng Chao, Ming Ting Wu

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

Brain abnormalities, as determined by structural magnetic resonance imaging (MRI), have been reported in patients with attention-deficit hyperactivity disorder (ADHD); however, female subjects have been underrepresented in previous reports. In this study, we used optimized voxel-based morphometry to compare the total and regional gray matter volumes between groups of 7- to 17-year-old ADHD and healthy children (total 114 subjects). Fifty-seven children with ADHD (n=57, 35 males and 22 females) and healthy children (n=57) received MRI scans. Segmented brain MRI images were normalized into standardized stereotactic space, modulated to allow volumetric analysis, smoothed and compared at the voxel level with statistical parametric mapping. Global volumetric comparisons between groups revealed that the total brain volumes of ADHD children were smaller than those of the control children. As for the regional brain analysis, the brain volumes of ADHD children were found to be bilaterally smaller in the following regions as compared with normal control values: the caudate nucleus and the cerebellum. There were two clusters of regional decrease in the female brain, left posterior cingulum and right precuneus, as compared with the male brain. Brain regions showing the interaction effect of diagnosis and gender were negligible. These results were consistent with the hypothesized dysfunctional systems in ADHD, and they also suggested that neuroanatomical abnormalities in ADHD were not influenced by gender.

原文English
頁(從 - 到)245-253
頁數9
期刊Psychiatry Research - Neuroimaging
164
發行號3
DOIs
出版狀態Published - 2008 十二月 30

All Science Journal Classification (ASJC) codes

  • 神經科學(雜項)
  • 放射學、核子醫學和影像學
  • 精神病學和心理健康

指紋

深入研究「Absence of gender effect on children with attention-deficit/hyperactivity disorder as assessed by optimized voxel-based morphometry」主題。共同形成了獨特的指紋。

引用此