Acetylation of nuclear factor-κB in rat amygdala improves long-term but not short-term retention of fear memory

Shiu Hwa Yeh, Chia Ho Lin, Po Wu Gean

研究成果: Article同行評審

178 引文 斯高帕斯(Scopus)

摘要

Memory consolidation is mediated by new protein synthesis. However, the transcriptional pathways induced in neurons by behavioral training that activate gene responses have yet to be fully delineated. We have previously shown that nuclear factor κB (NF-κB) is activated in the amygdala after fear conditioning. Here we report that fear conditioning resulted in an increase in histone acetyl-transferase activity, the association between NF-κB p65 and CBP, and the increase in acetylated p65. Pretreating animals with histone deacetylase (HDAC) inhibitors prolonged the nuclear expression of acetyl-p65 and increased its DNA binding activity. Consistent with these results, HDAC inhibitors enhanced long-term but not short-term fear memory, and this effect was attenuated by κB decoy DNA, whereas scrambled DNA was without effect. This study provides evidence that HDAC-mediated deacetylation functions as an intranuclear molecular switch culminating in the termination of NF-κB transcriptional response that is involved in the formation of fear memory.

原文English
頁(從 - 到)1286-1292
頁數7
期刊Molecular Pharmacology
65
發行號5
DOIs
出版狀態Published - 2004 五月

All Science Journal Classification (ASJC) codes

  • 分子醫學
  • 藥理

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