Actin-associated protein palladin is required for migration behavior and differentiation potential of C2C12 myoblast cells

Ngoc Uyen Nhi Nguyen, Vincent Roderick Liang, Hao-Ven Wang

研究成果: Article

8 引文 斯高帕斯(Scopus)

摘要

The actin-associated protein palladin has been shown to be involved in differentiation processes in non-muscle tissues. However, but its function in skeletal muscle has rarely been studied. Palladin plays important roles in the regulation of diverse actin-related signaling in a number of cell types. Since intact actin-cytoskeletal remodeling is necessary for myogenesis, in the present study, we pursue to investigate the role of actin-associated palladin in skeletal muscle differentiation. Palladin in C2C12 myoblasts is knocked-down using specific small interfering RNA (siRNA). The results show that down-regulation of palladin decreased migratory activity of mouse skeletal muscle C2C12 myoblasts. Furthermore, the depletion of palladin enhances C2C12 vitality and proliferation. Of note, the loss of palladin promotes C2C12 to express the myosin heavy chain, suggesting that palladin has a role in the modulation of C2C12 differentiation. It is thus proposed that palladin is required for normal C2C12 myogenesis in vitro.

原文English
頁(從 - 到)728-733
頁數6
期刊Biochemical and Biophysical Research Communications
452
發行號3
DOIs
出版狀態Published - 2014 九月 26

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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