Active micro-mixers using surface acoustic waves on Y-cut 128° LiNbO3

Wei Kuo Tseng, Jr Lung Lin, Wang Chou Sung, Shu Hui Chen, Gwo Bin Lee

研究成果: Article同行評審

118 引文 斯高帕斯(Scopus)


This study presents an active method for micro-mixers using surface acoustic waves (SAW) to rapidly mix co-fluent fluids. Mixing is challenging work in microfluidic systems due to their low-Reynolds-number flow conditions. SAW devices were fabricated on 128° Y-cut lithium niobate (LiNbO3). The micro-mixers are these piezoelectric actuators integrated with polydimethylsiloxane microchannels. The effects of the applied voltages on interdigitated transducers (IDTs) and two layouts, parallel- and transversal-type, of micro-mixers on the mixing performance were experimentally explored. The experimental results revealed that the parallel-type mixer achieved a higher mixing effect. Meanwhile, a higher applied voltage on the IDTs led to a significant improvement in the mixing performance of the active micro-mixer. Typical temperature effects associated with the applied voltages on the IDTs were also investigated. Finally, a digestion reaction between a protein (hemoglobin) and an enzyme (trypsin) was performed to verify the capability of the micro-mixers. The protein-enzyme mixture was qualitatively analyzed using mass spectrometry. Using these SAW-based mixers, the amount of digested peptides increased. Additionally, the protein-enzyme mixture was also quantitatively analyzed using high-performance liquid chromatography. Experimental data showed that the amount of digested peptides increased 21.1% using the active mixer. Therefore, the developed micro-mixers can be applied in microfluidic systems for improving mixing efficiency and thus enhancing the bio-reaction.

頁(從 - 到)539-548
期刊Journal of Micromechanics and Microengineering
出版狀態Published - 2006 三月 1

All Science Journal Classification (ASJC) codes

  • 電子、光磁材料
  • 材料力學
  • 機械工業
  • 電氣與電子工程


深入研究「Active micro-mixers using surface acoustic waves on Y-cut 128° LiNbO<sub>3</sub>」主題。共同形成了獨特的指紋。