Added value of a serum proteomic signature in the diagnostic evaluation of lung nodules

Chad V. Pecot, Ming Li, Xueqiong J. Zhang, Rama Rajanbabu, Ciara Calitri, Aaron Bungum, James R. Jett, Joe B. Putnam, Carol Callaway-Lane, Steve Deppen, Eric L. Grogan, David P. Carbone, John A. Worrell, Karel G.M. Moons, Yu Shyr, Pierre P. Massion

研究成果: Article同行評審

47 引文 斯高帕斯(Scopus)

摘要

Background: Current management of lung nodules is complicated by nontherapeutic resections and missed chances for cure. We hypothesized that a serum proteomic signature may add diagnostic information beyond that provided by combined clinical and radiographic data. Methods: Cohort A included 265 and cohort B 114 patients. Using multivariable logistic regression analysis we calculated the area under the receiver operating characteristic curve (AUC) and quantified the added value of a previously described serum proteomic signature beyond clinical and radiographic risk factors for predicting lung cancer using the integration discrimination improvement (IDI) index. Results: The average computed tomography (CT) measured nodule size in cohorts A and B was 37.83 versus 23.15 mm among patients with lung cancer and 15.82 versus 17.18 mm among those without, respectively. In cohort A, the AUC increased from 0.68 to 0.86 after adding chest CT imaging variables to the clinical results, but the proteomic signature did not provide meaningful added value. In contrast, in cohort B, the AUC improved from 0.46 with clinical data alone to 0.61 when combined with chest CT imaging data and to 0.69 after adding the proteomic signature (IDI of 20% P=0.0003). In addition, in a subgroup of 100 nodules between 5 and 20mm in diameter, the proteomic signature added value with an IDI of 15% (P < 0.0001). Conclusions: The results show that this serum proteomic biomarker signature may add value to the clinical and chest CT evaluation of indeterminate lung nodules. Impact: This study suggests a possible role of a blood biomarker in the evaluation of indeterminate lung nodules.

原文English
頁(從 - 到)786-792
頁數7
期刊Cancer Epidemiology Biomarkers and Prevention
21
發行號5
DOIs
出版狀態Published - 2012 五月

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

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