摘要
BACKGROUND: We evaluated the interaction of dopamine–proxymetacaine and dopamine–oxybuprocaine antinociception using isobolograms. METHODS: This experiment uses subcutaneous drug (proxymetacaine, oxybuprocaine, and dopamine) injections under the skin of the rat’s back, thus simulating infiltration blocks. The doserelated antinociceptive curves of proxymetacaine and oxybuprocaine alone and in combination with dopamine were constructed, and then the antinociceptive interactions between the local anesthetic and dopamine were analyzed using isobolograms. RESULTS: Subcutaneous proxymetacaine, oxybuprocaine, and dopamine produced a sensory block to local skin pinpricks in a dosedependent fashion. The rank order of potency was proxymetacaine (0.57 [0.52–0.63] µmol/kg) > oxybuprocaine (1.05 [0.96–1.15] µmol/kg) > dopamine (165 [154–177] µmol/kg; P < .01 for each comparison) based on the 50% effective dose values. On the equianesthetic basis (25% effective dose, 50% effective dose, and 75% effective dose), the nociceptive block duration of proxymetacaine or oxybuprocaine was shorter than that of dopamine (P < .01). Oxybuprocaine or proxymetacaine coinjected with dopamine elicited a synergistic antinociceptive effect and extended the duration of action. CONCLUSIONS: Oxybuprocaine and proxymetacaine had a higher potency and provoked a shorter duration of sensory block compared with dopamine. The use of dopamine increased the quality and duration of skin antinociception caused by oxybuprocaine and proxymetacaine. (Anesth Analg 2018;126:1721–8.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 1721-1728 |
| 頁數 | 8 |
| 期刊 | Anesthesia and Analgesia |
| 卷 | 126 |
| 發行號 | 5 |
| DOIs | |
| 出版狀態 | Published - 2018 五月 1 |
指紋
All Science Journal Classification (ASJC) codes
- Anesthesiology and Pain Medicine
引用此文
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Adding dopamine to proxymetacaine or oxybuprocaine solutions potentiates and prolongs the cutaneous antinociception in rats. / Chen, Yu Wen; Chiu, Chong Chi; Lin, Heng Teng; Wang, Jhi Joung; Hung, Ching-Hsia.
於: Anesthesia and Analgesia, 卷 126, 編號 5, 01.05.2018, p. 1721-1728.研究成果: Article
TY - JOUR
T1 - Adding dopamine to proxymetacaine or oxybuprocaine solutions potentiates and prolongs the cutaneous antinociception in rats
AU - Chen, Yu Wen
AU - Chiu, Chong Chi
AU - Lin, Heng Teng
AU - Wang, Jhi Joung
AU - Hung, Ching-Hsia
PY - 2018/5/1
Y1 - 2018/5/1
N2 - BACKGROUND: We evaluated the interaction of dopamine–proxymetacaine and dopamine–oxybuprocaine antinociception using isobolograms. METHODS: This experiment uses subcutaneous drug (proxymetacaine, oxybuprocaine, and dopamine) injections under the skin of the rat’s back, thus simulating infiltration blocks. The doserelated antinociceptive curves of proxymetacaine and oxybuprocaine alone and in combination with dopamine were constructed, and then the antinociceptive interactions between the local anesthetic and dopamine were analyzed using isobolograms. RESULTS: Subcutaneous proxymetacaine, oxybuprocaine, and dopamine produced a sensory block to local skin pinpricks in a dosedependent fashion. The rank order of potency was proxymetacaine (0.57 [0.52–0.63] µmol/kg) > oxybuprocaine (1.05 [0.96–1.15] µmol/kg) > dopamine (165 [154–177] µmol/kg; P < .01 for each comparison) based on the 50% effective dose values. On the equianesthetic basis (25% effective dose, 50% effective dose, and 75% effective dose), the nociceptive block duration of proxymetacaine or oxybuprocaine was shorter than that of dopamine (P < .01). Oxybuprocaine or proxymetacaine coinjected with dopamine elicited a synergistic antinociceptive effect and extended the duration of action. CONCLUSIONS: Oxybuprocaine and proxymetacaine had a higher potency and provoked a shorter duration of sensory block compared with dopamine. The use of dopamine increased the quality and duration of skin antinociception caused by oxybuprocaine and proxymetacaine. (Anesth Analg 2018;126:1721–8.
AB - BACKGROUND: We evaluated the interaction of dopamine–proxymetacaine and dopamine–oxybuprocaine antinociception using isobolograms. METHODS: This experiment uses subcutaneous drug (proxymetacaine, oxybuprocaine, and dopamine) injections under the skin of the rat’s back, thus simulating infiltration blocks. The doserelated antinociceptive curves of proxymetacaine and oxybuprocaine alone and in combination with dopamine were constructed, and then the antinociceptive interactions between the local anesthetic and dopamine were analyzed using isobolograms. RESULTS: Subcutaneous proxymetacaine, oxybuprocaine, and dopamine produced a sensory block to local skin pinpricks in a dosedependent fashion. The rank order of potency was proxymetacaine (0.57 [0.52–0.63] µmol/kg) > oxybuprocaine (1.05 [0.96–1.15] µmol/kg) > dopamine (165 [154–177] µmol/kg; P < .01 for each comparison) based on the 50% effective dose values. On the equianesthetic basis (25% effective dose, 50% effective dose, and 75% effective dose), the nociceptive block duration of proxymetacaine or oxybuprocaine was shorter than that of dopamine (P < .01). Oxybuprocaine or proxymetacaine coinjected with dopamine elicited a synergistic antinociceptive effect and extended the duration of action. CONCLUSIONS: Oxybuprocaine and proxymetacaine had a higher potency and provoked a shorter duration of sensory block compared with dopamine. The use of dopamine increased the quality and duration of skin antinociception caused by oxybuprocaine and proxymetacaine. (Anesth Analg 2018;126:1721–8.
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U2 - 10.1213/ANE.0000000000002635
DO - 10.1213/ANE.0000000000002635
M3 - Article
C2 - 29381510
AN - SCOPUS:85053915142
VL - 126
SP - 1721
EP - 1728
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 5
ER -