TY - GEN
T1 - Addressable light-induced heat knockdown (aLINK) for caenorhabditis (C.) elegans immobilization
AU - Chuang, Han Sheng
AU - Chiu, Wen Tai
AU - Chen, Cheng Shi
PY - 2012
Y1 - 2012
N2 - Caenorhabditis (C.) elegans is an intriguing model animal. Often times, researchers may need to silence the squirming worms and brought them to various measurements. Here we present a method to rapidly silence the tiny animal by sublethal light-induced heat in a special microfluidic chip. The worm's neural functions are temporarily shut down when a threshold temperature is reached. The neural functions can be resumed once the heat is removed. A safe operating range as to inducing heat knockdown was investigated. The finding showed that well-controlled heat knockdown is autonomous, reversible, and potential to worm immobilization.
AB - Caenorhabditis (C.) elegans is an intriguing model animal. Often times, researchers may need to silence the squirming worms and brought them to various measurements. Here we present a method to rapidly silence the tiny animal by sublethal light-induced heat in a special microfluidic chip. The worm's neural functions are temporarily shut down when a threshold temperature is reached. The neural functions can be resumed once the heat is removed. A safe operating range as to inducing heat knockdown was investigated. The finding showed that well-controlled heat knockdown is autonomous, reversible, and potential to worm immobilization.
UR - http://www.scopus.com/inward/record.url?scp=84901811438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901811438&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84901811438
SN - 9780979806452
T3 - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
SP - 365
EP - 367
BT - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PB - Chemical and Biological Microsystems Society
T2 - 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Y2 - 28 October 2012 through 1 November 2012
ER -