Addressable light-induced heat knockdown (aLINK) for caenorhabditis (C.) elegans immobilization

研究成果: Conference contribution

摘要

Caenorhabditis (C.) elegans is an intriguing model animal. Often times, researchers may need to silence the squirming worms and brought them to various measurements. Here we present a method to rapidly silence the tiny animal by sublethal light-induced heat in a special microfluidic chip. The worm's neural functions are temporarily shut down when a threshold temperature is reached. The neural functions can be resumed once the heat is removed. A safe operating range as to inducing heat knockdown was investigated. The finding showed that well-controlled heat knockdown is autonomous, reversible, and potential to worm immobilization.

原文English
主出版物標題Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
發行者Chemical and Biological Microsystems Society
頁面365-367
頁數3
ISBN(列印)9780979806452
出版狀態Published - 2012 一月 1
事件16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
持續時間: 2012 十月 282012 十一月 1

出版系列

名字Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
國家Japan
城市Okinawa
期間12-10-2812-11-01

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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