Adenoma‐carcinoma sequence: A reappraisal with immunohistochemical expression of ferritin

Hsiao‐Bai ‐B Yang, Ping‐I ‐I Hsu, Jen‐Chang ‐C Lee, Shih‐Huang ‐H Chan, Xi‐Zhang ‐Z Lin, Nan‐Haw ‐H Chow

研究成果: Article

18 引文 (Scopus)

摘要

To examine the biological significance of ferritin (FRN) expression, a retrospective immunohistochemical study was performed in normal coIonic mucosae (n = 8), adenomas (n = 88), and colorectal carcinomas (n = 104). FRN was present in some epithelia in the crypt base of normal colonic mucosae. Significant cytoplasmic staining for FRN was revealed in 26 (29.5%) cases of adenoma and 54 cases (51.9%) of adenocarcinoma. The cancer cells had a higher proportion of FRN expression than those of adenomas or non‐neoplastic mucosae (P < 0.001). Expression of FRN showed a positive association with the degree of dysplasia (P = 0.039) and the distal location of adenoma (P = 0.013). FRN expression tended to be associated with the tumor size (P = 0.083), but no substantial difference was observed among the histologic types of adenoma (P = 0.754). The results suggest that cytoplasmic FRN expression is associated with cellular proliferation. The proliferative index shows a significant difference through the adenoma‐carcinoma sequence. Further investigation is necessary to clarify the clinical implication of FRN expression in tumor cells and normal‐appearing mucosae. © 1995 Wiley‐Liss, Inc.

原文English
頁(從 - 到)35-40
頁數6
期刊Journal of Surgical Oncology
60
發行號1
DOIs
出版狀態Published - 1995 九月

指紋

Ferritins
Adenoma
Mucous Membrane
Neoplasms
Colorectal Neoplasms
Adenocarcinoma
Epithelium
Retrospective Studies
Cell Proliferation
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

引用此文

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abstract = "To examine the biological significance of ferritin (FRN) expression, a retrospective immunohistochemical study was performed in normal coIonic mucosae (n = 8), adenomas (n = 88), and colorectal carcinomas (n = 104). FRN was present in some epithelia in the crypt base of normal colonic mucosae. Significant cytoplasmic staining for FRN was revealed in 26 (29.5{\%}) cases of adenoma and 54 cases (51.9{\%}) of adenocarcinoma. The cancer cells had a higher proportion of FRN expression than those of adenomas or non‐neoplastic mucosae (P < 0.001). Expression of FRN showed a positive association with the degree of dysplasia (P = 0.039) and the distal location of adenoma (P = 0.013). FRN expression tended to be associated with the tumor size (P = 0.083), but no substantial difference was observed among the histologic types of adenoma (P = 0.754). The results suggest that cytoplasmic FRN expression is associated with cellular proliferation. The proliferative index shows a significant difference through the adenoma‐carcinoma sequence. Further investigation is necessary to clarify the clinical implication of FRN expression in tumor cells and normal‐appearing mucosae. {\circledC} 1995 Wiley‐Liss, Inc.",
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Adenoma‐carcinoma sequence : A reappraisal with immunohistochemical expression of ferritin. / Yang, Hsiao‐Bai ‐B; Hsu, Ping‐I ‐I; Lee, Jen‐Chang ‐C; Chan, Shih‐Huang ‐H; Lin, Xi‐Zhang ‐Z; Chow, Nan‐Haw ‐H.

於: Journal of Surgical Oncology, 卷 60, 編號 1, 09.1995, p. 35-40.

研究成果: Article

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T2 - A reappraisal with immunohistochemical expression of ferritin

AU - Yang, Hsiao‐Bai ‐B

AU - Hsu, Ping‐I ‐I

AU - Lee, Jen‐Chang ‐C

AU - Chan, Shih‐Huang ‐H

AU - Lin, Xi‐Zhang ‐Z

AU - Chow, Nan‐Haw ‐H

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N2 - To examine the biological significance of ferritin (FRN) expression, a retrospective immunohistochemical study was performed in normal coIonic mucosae (n = 8), adenomas (n = 88), and colorectal carcinomas (n = 104). FRN was present in some epithelia in the crypt base of normal colonic mucosae. Significant cytoplasmic staining for FRN was revealed in 26 (29.5%) cases of adenoma and 54 cases (51.9%) of adenocarcinoma. The cancer cells had a higher proportion of FRN expression than those of adenomas or non‐neoplastic mucosae (P < 0.001). Expression of FRN showed a positive association with the degree of dysplasia (P = 0.039) and the distal location of adenoma (P = 0.013). FRN expression tended to be associated with the tumor size (P = 0.083), but no substantial difference was observed among the histologic types of adenoma (P = 0.754). The results suggest that cytoplasmic FRN expression is associated with cellular proliferation. The proliferative index shows a significant difference through the adenoma‐carcinoma sequence. Further investigation is necessary to clarify the clinical implication of FRN expression in tumor cells and normal‐appearing mucosae. © 1995 Wiley‐Liss, Inc.

AB - To examine the biological significance of ferritin (FRN) expression, a retrospective immunohistochemical study was performed in normal coIonic mucosae (n = 8), adenomas (n = 88), and colorectal carcinomas (n = 104). FRN was present in some epithelia in the crypt base of normal colonic mucosae. Significant cytoplasmic staining for FRN was revealed in 26 (29.5%) cases of adenoma and 54 cases (51.9%) of adenocarcinoma. The cancer cells had a higher proportion of FRN expression than those of adenomas or non‐neoplastic mucosae (P < 0.001). Expression of FRN showed a positive association with the degree of dysplasia (P = 0.039) and the distal location of adenoma (P = 0.013). FRN expression tended to be associated with the tumor size (P = 0.083), but no substantial difference was observed among the histologic types of adenoma (P = 0.754). The results suggest that cytoplasmic FRN expression is associated with cellular proliferation. The proliferative index shows a significant difference through the adenoma‐carcinoma sequence. Further investigation is necessary to clarify the clinical implication of FRN expression in tumor cells and normal‐appearing mucosae. © 1995 Wiley‐Liss, Inc.

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