Adequacy of nutrition and body weight in patients with early stage dementia: The cognition and aging study

Hua Tsen Hsiao, Jun Jun Lee, Hsiu Hui Chen, Ming Kung Wu, Chi Wei Huang, Ya Ting Chang, Chia Yi Lien, Jing Jy Wang, Hsin I. Chang, Chiung Chih Chang

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)


Background & aims: Recent evidence highlights the effects of obesity, diabetes and hypertension in the development of Alzheimer's disease. Involuntary body weight changes in patients with different stages of dementia can be related to clinical factors of the patient per se or support from their caregivers. Understanding the interactions among factors is important to establish a monitoring paradigm to guide treatment strategies. Methods: A total of 345 patients with very mild (n = 224) and mild stage (n = 121) dementia were enrolled from a multi-disciplinary dementia clinic. Clinical data (comorbidities, Mini-Mental State Examination [MMSE] scores, neuropsychiatric inventory [NPI] scores, eating behavior questionnaire), nutritional state (Mini-Nutritional Assessment [MNA] or MNA short form [MNA-SF]) and body mass index (BMI) were recorded. Nutritional state and BMI served as the two major outcome measures, and factors for analysis included diagnosis, dementia severity and clinical data. Results: There was a significant correlation between MNA-SF and MNA (r = .898, p < 0.01), but a 24% mismatch in case dislocation was found using the at-risk or malnutrition criteria. Factors related to obesity included male sex, higher MNA-SF and MNA scores, diabetes mellitus and hypertension, while acceptable discrimination for obesity (BMI≧23 kg/m2) was obtained with a MNA-SF score of 12/13 or MNA score of 21/22. NPI was the only independent factor related to both MNA-SF (β = −.06, P < 0.001) and MNA (β = −.1, P < 0.001). A BMI of 22–23 kg/m2 was adequate in this group of patients with early stage dementia from nutritional and comorbidity perspectives. After controlling for BMI, the patients with advanced dementia had higher swallowing problem and appetite change scores. Conclusions: In these patients with early stage dementia, a higher BMI indicated adequate nutritional status and higher MMSE, but also higher rates of comorbidities, diabetes mellitus and hypertension.

頁(從 - 到)2187-2194
期刊Clinical Nutrition
出版狀態Published - 2019 10月

All Science Journal Classification (ASJC) codes

  • 營養與營養學
  • 重症監護和重症監護醫學


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