Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication

Chiao-Hsiung Chuang, Bor-Shyang Sheu, Ai Wen Kao, Hsiu-Chi Cheng, Ay Huey Huang, Hsiao Bai Yang, Jiunn Jong Wu

研究成果: Article

18 引文 (Scopus)

摘要

Background/Aims: To test the impact of vitamin C supplementation on triple therapy for H. pylori eradication. Methodology: A total of 171 H. pylori-infected patients were randomized to receive different one-week triple therapies, including 20mg omeprazole, 1g amoxicillin, plus the following twice daily: 1) 250mg clarithromycin (C250 group, n=55); 2) 250mg clarithromycin and 500mg vitamin C (V-C250 group, n=61); 3) 500mg clarithromycin (C500 group, n=55). Six weeks after treatment, the success of H. pylori eradication was assessed by a 13C-urea breath test. Each collected H. pylori strain was defined as either clarithromycin susceptible or resistant by E-test. Results: The demographic background, clarithromycin susceptibility of H. pylori, and drug compliance were similar among the three groups (p=NS). For clarithromycin susceptible infection, the V-C250 group had a higher eradication rate than the C250 group (ITT: 85% us. 68% and PP: 90% us. 73%,p=0.03), but had an equivalent rate to the C500 group (p=NS). For clarithromycin resistant infection, all three groups had a similarly poor eradication rate of less than 34%. Conclusions: Adding vitamin C to one-week triple therapy can reduce the dosage of clarithromycin, but preserve the high eradication efficacy for clarithromycin susceptible H. pylori infection.

原文English
頁(從 - 到)320-324
頁數5
期刊Hepato-Gastroenterology
54
發行號73
出版狀態Published - 2007 一月

指紋

Clarithromycin
Omeprazole
Amoxicillin
Helicobacter pylori
Ascorbic Acid
Therapeutics
Breath Tests
Helicobacter Infections
Infection
Urea
Demography

All Science Journal Classification (ASJC) codes

  • Gastroenterology

引用此文

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title = "Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication",
abstract = "Background/Aims: To test the impact of vitamin C supplementation on triple therapy for H. pylori eradication. Methodology: A total of 171 H. pylori-infected patients were randomized to receive different one-week triple therapies, including 20mg omeprazole, 1g amoxicillin, plus the following twice daily: 1) 250mg clarithromycin (C250 group, n=55); 2) 250mg clarithromycin and 500mg vitamin C (V-C250 group, n=61); 3) 500mg clarithromycin (C500 group, n=55). Six weeks after treatment, the success of H. pylori eradication was assessed by a 13C-urea breath test. Each collected H. pylori strain was defined as either clarithromycin susceptible or resistant by E-test. Results: The demographic background, clarithromycin susceptibility of H. pylori, and drug compliance were similar among the three groups (p=NS). For clarithromycin susceptible infection, the V-C250 group had a higher eradication rate than the C250 group (ITT: 85{\%} us. 68{\%} and PP: 90{\%} us. 73{\%},p=0.03), but had an equivalent rate to the C500 group (p=NS). For clarithromycin resistant infection, all three groups had a similarly poor eradication rate of less than 34{\%}. Conclusions: Adding vitamin C to one-week triple therapy can reduce the dosage of clarithromycin, but preserve the high eradication efficacy for clarithromycin susceptible H. pylori infection.",
author = "Chiao-Hsiung Chuang and Bor-Shyang Sheu and Kao, {Ai Wen} and Hsiu-Chi Cheng and Huang, {Ay Huey} and Yang, {Hsiao Bai} and Wu, {Jiunn Jong}",
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Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication. / Chuang, Chiao-Hsiung; Sheu, Bor-Shyang; Kao, Ai Wen; Cheng, Hsiu-Chi; Huang, Ay Huey; Yang, Hsiao Bai; Wu, Jiunn Jong.

於: Hepato-Gastroenterology, 卷 54, 編號 73, 01.2007, p. 320-324.

研究成果: Article

TY - JOUR

T1 - Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication

AU - Chuang, Chiao-Hsiung

AU - Sheu, Bor-Shyang

AU - Kao, Ai Wen

AU - Cheng, Hsiu-Chi

AU - Huang, Ay Huey

AU - Yang, Hsiao Bai

AU - Wu, Jiunn Jong

PY - 2007/1

Y1 - 2007/1

N2 - Background/Aims: To test the impact of vitamin C supplementation on triple therapy for H. pylori eradication. Methodology: A total of 171 H. pylori-infected patients were randomized to receive different one-week triple therapies, including 20mg omeprazole, 1g amoxicillin, plus the following twice daily: 1) 250mg clarithromycin (C250 group, n=55); 2) 250mg clarithromycin and 500mg vitamin C (V-C250 group, n=61); 3) 500mg clarithromycin (C500 group, n=55). Six weeks after treatment, the success of H. pylori eradication was assessed by a 13C-urea breath test. Each collected H. pylori strain was defined as either clarithromycin susceptible or resistant by E-test. Results: The demographic background, clarithromycin susceptibility of H. pylori, and drug compliance were similar among the three groups (p=NS). For clarithromycin susceptible infection, the V-C250 group had a higher eradication rate than the C250 group (ITT: 85% us. 68% and PP: 90% us. 73%,p=0.03), but had an equivalent rate to the C500 group (p=NS). For clarithromycin resistant infection, all three groups had a similarly poor eradication rate of less than 34%. Conclusions: Adding vitamin C to one-week triple therapy can reduce the dosage of clarithromycin, but preserve the high eradication efficacy for clarithromycin susceptible H. pylori infection.

AB - Background/Aims: To test the impact of vitamin C supplementation on triple therapy for H. pylori eradication. Methodology: A total of 171 H. pylori-infected patients were randomized to receive different one-week triple therapies, including 20mg omeprazole, 1g amoxicillin, plus the following twice daily: 1) 250mg clarithromycin (C250 group, n=55); 2) 250mg clarithromycin and 500mg vitamin C (V-C250 group, n=61); 3) 500mg clarithromycin (C500 group, n=55). Six weeks after treatment, the success of H. pylori eradication was assessed by a 13C-urea breath test. Each collected H. pylori strain was defined as either clarithromycin susceptible or resistant by E-test. Results: The demographic background, clarithromycin susceptibility of H. pylori, and drug compliance were similar among the three groups (p=NS). For clarithromycin susceptible infection, the V-C250 group had a higher eradication rate than the C250 group (ITT: 85% us. 68% and PP: 90% us. 73%,p=0.03), but had an equivalent rate to the C500 group (p=NS). For clarithromycin resistant infection, all three groups had a similarly poor eradication rate of less than 34%. Conclusions: Adding vitamin C to one-week triple therapy can reduce the dosage of clarithromycin, but preserve the high eradication efficacy for clarithromycin susceptible H. pylori infection.

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