This paper explores the potential of geographic information system (GIS) in disaster prevention education. Open source GIS is applied to build a disaster prevention education system used to assist students in strengthening their knowledge of typhoon prevention and enhancing awareness of typhoon disaster. An experiment which the technology acceptance model was applied as the theoretical fundamental was designed to investigate students' intention on using the system. A total of 34 university students participated in using the proposed system. Results show that (1) perceived ease of use has a positive and significant influence on attitude toward use and perceived usefulness; (2) perceived usefulness has a positive and significant influence on attitude toward use and behavioral intentions; (3) attitude toward usage does not have a significant influence on the students' intention to use the system.