Adrenal myelolipoma with translocation (3;21)(q25;p11)

Kong Chao Chang, Pei Ih Chen, Zen Hung Huang, Yung Ming Lin, Pao Lin Kuo

研究成果: Article同行評審

63 引文 斯高帕斯(Scopus)

摘要

Adrenal myelolipoma (ML) is a rare, benign, nonfunctioning tumor-like lesion composed of mature adipose tissue interspersed with bone marrow-like hematopoietic elements in various proportions. It occurs usually in adults and is frequently asymptomatic in about half of cases. The histogenesis of adrenal ML is not clear and this lesion has been found to be associated with endocrine disorders, other adrenal dysfunction and tumors, and hyperstimulation with adrenocorticotropic hormone. Specific chromosomal abnormalities, however, have not been observed in such cases. Herein, we report a typical case of adrenal ML found incidentally in a 26-year-old man. Conventional cytogenetic techniques demonstrated balanced translocation between bands 3q25 and 21p11 in 9 of 20 metaphases analyzed in cultured tumor cells. To the best of our knowledge, this is the first reported case of adrenal ML showing chromosomal abnormality. This finding would indicate that adrenal ML is a bona fide neoplasm and the possibility of derivation from misplaced hematopoietic cells may be alternatively taken into consideration in view of the similar genetic changes in hematopolietic neoplasms.

原文English
頁(從 - 到)77-80
頁數4
期刊Cancer Genetics and Cytogenetics
134
發行號1
DOIs
出版狀態Published - 2002 四月 1

All Science Journal Classification (ASJC) codes

  • 分子生物學
  • 遺傳學
  • 癌症研究

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