Advances in Noninvasive Functional Imaging of Bone

Sheng Min Lan, Ya Na Wu, Ping Ching Wu, Chi Kuang Sun, Dar Bin Shieh, Ruey Mo Lin

研究成果: Review article同行評審

4 引文 斯高帕斯(Scopus)


The demand for functional imaging in clinical medicine is comprehensive. Although the gold standard for the functional imaging of human bones in clinical settings is still radionuclide-based imaging modalities, nonionizing noninvasive imaging technology in small animals has greatly advanced in recent decades, especially the diffuse optical imaging to which Britton Chance made tremendous contributions. The evolution of imaging probes, instruments, and computation has facilitated exploration in the complicated biomedical research field by allowing longitudinal observation of molecular events in live cells and animals. These research-imaging tools are being used for clinical applications in various specialties, such as oncology, neuroscience, and dermatology. The Bone, a deeply located mineralized tissue, presents a challenge for noninvasive functional imaging in humans. Using nanoparticles (NP) with multiple favorable properties as bioimaging probes has provided orthopedics an opportunity to benefit from these noninvasive bone-imaging techniques. This review highlights the historical evolution of radionuclide-based imaging, computed tomography, positron emission tomography, and magnetic resonance imaging, diffuse optics-enabled in vivo technologies, vibrational spectroscopic imaging, and a greater potential for using NPs for biomedical imaging.

頁(從 - 到)281-301
期刊Academic Radiology
出版狀態Published - 2014 2月

All Science Journal Classification (ASJC) codes

  • 放射學、核子醫學和影像學


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