摘要
The demand for functional imaging in clinical medicine is comprehensive. Although the gold standard for the functional imaging of human bones in clinical settings is still radionuclide-based imaging modalities, nonionizing noninvasive imaging technology in small animals has greatly advanced in recent decades, especially the diffuse optical imaging to which Britton Chance made tremendous contributions. The evolution of imaging probes, instruments, and computation has facilitated exploration in the complicated biomedical research field by allowing longitudinal observation of molecular events in live cells and animals. These research-imaging tools are being used for clinical applications in various specialties, such as oncology, neuroscience, and dermatology. The Bone, a deeply located mineralized tissue, presents a challenge for noninvasive functional imaging in humans. Using nanoparticles (NP) with multiple favorable properties as bioimaging probes has provided orthopedics an opportunity to benefit from these noninvasive bone-imaging techniques. This review highlights the historical evolution of radionuclide-based imaging, computed tomography, positron emission tomography, and magnetic resonance imaging, diffuse optics-enabled in vivo technologies, vibrational spectroscopic imaging, and a greater potential for using NPs for biomedical imaging.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 281-301 |
| 頁數 | 21 |
| 期刊 | Academic Radiology |
| 卷 | 21 |
| 發行號 | 2 |
| DOIs | |
| 出版狀態 | Published - 2014 二月 1 |
指紋
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
引用此文
}
Advances in Noninvasive Functional Imaging of Bone. / Lan, Sheng Min; Wu, Ya Na; Wu, Ping Ching; Sun, Chi Kuang; Shieh, Dar Bin; Lin, Ruey Mo.
於: Academic Radiology, 卷 21, 編號 2, 01.02.2014, p. 281-301.研究成果: Review article
TY - JOUR
T1 - Advances in Noninvasive Functional Imaging of Bone
AU - Lan, Sheng Min
AU - Wu, Ya Na
AU - Wu, Ping Ching
AU - Sun, Chi Kuang
AU - Shieh, Dar Bin
AU - Lin, Ruey Mo
PY - 2014/2/1
Y1 - 2014/2/1
N2 - The demand for functional imaging in clinical medicine is comprehensive. Although the gold standard for the functional imaging of human bones in clinical settings is still radionuclide-based imaging modalities, nonionizing noninvasive imaging technology in small animals has greatly advanced in recent decades, especially the diffuse optical imaging to which Britton Chance made tremendous contributions. The evolution of imaging probes, instruments, and computation has facilitated exploration in the complicated biomedical research field by allowing longitudinal observation of molecular events in live cells and animals. These research-imaging tools are being used for clinical applications in various specialties, such as oncology, neuroscience, and dermatology. The Bone, a deeply located mineralized tissue, presents a challenge for noninvasive functional imaging in humans. Using nanoparticles (NP) with multiple favorable properties as bioimaging probes has provided orthopedics an opportunity to benefit from these noninvasive bone-imaging techniques. This review highlights the historical evolution of radionuclide-based imaging, computed tomography, positron emission tomography, and magnetic resonance imaging, diffuse optics-enabled in vivo technologies, vibrational spectroscopic imaging, and a greater potential for using NPs for biomedical imaging.
AB - The demand for functional imaging in clinical medicine is comprehensive. Although the gold standard for the functional imaging of human bones in clinical settings is still radionuclide-based imaging modalities, nonionizing noninvasive imaging technology in small animals has greatly advanced in recent decades, especially the diffuse optical imaging to which Britton Chance made tremendous contributions. The evolution of imaging probes, instruments, and computation has facilitated exploration in the complicated biomedical research field by allowing longitudinal observation of molecular events in live cells and animals. These research-imaging tools are being used for clinical applications in various specialties, such as oncology, neuroscience, and dermatology. The Bone, a deeply located mineralized tissue, presents a challenge for noninvasive functional imaging in humans. Using nanoparticles (NP) with multiple favorable properties as bioimaging probes has provided orthopedics an opportunity to benefit from these noninvasive bone-imaging techniques. This review highlights the historical evolution of radionuclide-based imaging, computed tomography, positron emission tomography, and magnetic resonance imaging, diffuse optics-enabled in vivo technologies, vibrational spectroscopic imaging, and a greater potential for using NPs for biomedical imaging.
UR - http://www.scopus.com/inward/record.url?scp=84892461791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892461791&partnerID=8YFLogxK
U2 - 10.1016/j.acra.2013.11.016
DO - 10.1016/j.acra.2013.11.016
M3 - Review article
C2 - 24439341
AN - SCOPUS:84892461791
VL - 21
SP - 281
EP - 301
JO - Academic Radiology
JF - Academic Radiology
SN - 1076-6332
IS - 2
ER -