Advances in nonlinear optical microscopy for visualizing dynamic tissue properties in culture

Alvin T. Yeh, Holly Gibbs, Jin Jia Hu, Adam M. Larson

研究成果: Review article同行評審

17 引文 斯高帕斯(Scopus)

摘要

Optical microscopy encompasses high-resolution imaging techniques that can be used to non-destructively investigate and characterize living biological systems and engineered tissue constructs in culture. In particular, nonlinear optical microscopy (NLOM) is well suited for the visualization and quantification of processes involved in cell-extracellular matrix interactions in vivo. Current NLOM technology enables concomitant molecular imaging and visualization of microstructural organization that could provide a direct link between signal transduction and biological effect at microscopic length scales that culminate into tissue macroscopic properties and function. This review highlights the fundamentals of nonlinear optical interactions between light and tissue and presents a direction for future technology development to better complement quantitative, high-throughput assays of the modern life sciences.

原文English
頁(從 - 到)119-131
頁數13
期刊Tissue Engineering - Part B: Reviews
14
發行號1
DOIs
出版狀態Published - 2008 三月 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

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