摘要
Ajuga taiwanensis is widely used for the treatment of hepatitis and hepatoma in Taiwanese folk medicine. However, its bioactive components and mechanism of action are unclear. Herein, ajugalide-B (ATMA), a neoclerodane diterpenoid isolated from Ajuga taiwanensis, is reported to exhibit high anti-proliferative activity against tumor cell lines from various tissues. These results demonstrate that ATMA disrupts the focal adhesion complex by decreasing phosphorylation of paxillin and focal adhesion kinase (FAK). As a result, anoikis, a specific type of apoptosis caused by detachment of cells, is triggered by activation of caspase-8 in A549 cells. Furthermore, ATMA also blocks anchorage-independent growth and cell migration and, therefore, ATMA may serve as a lead compound for the developing of anti-cancer therapeuties with anoikis-inducing properties.
原文 | English |
---|---|
頁(從 - 到) | 64-69 |
頁數 | 6 |
期刊 | Phytochemistry |
卷 | 80 |
DOIs | |
出版狀態 | Published - 2012 8月 |
All Science Journal Classification (ASJC) codes
- 生物化學
- 分子生物學
- 植物科學
- 園藝科學