TY - JOUR
T1 - Akt
T2 - a key transducer in cancer
AU - Tsai, Pei Jane
AU - Lai, Yi Hsin
AU - Manne, Rajesh Kumar
AU - Tsai, Yau Sheng
AU - Sarbassov, Dos
AU - Lin, Hui Kuan
N1 - Funding Information:
This work is supported in part by National Institute of Health (NIH) Grants (R01CA248037 and R01CA264020) and to H.K.L and the Grant, AP08857553, from the Ministry of Education and Science of the Republic of Kazakhstan, to D.D.S.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Growth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its deregulation has been linked to various human diseases. Akt kinase is a central player transmitting extracellular clues to various cellular compartments, in turn executing these biological processes. Since the discovery of Akt three decades ago, the tremendous progress towards identifying its upstream regulators and downstream effectors and its roles in cancer has been made, offering novel paradigms and therapeutic strategies for targeting human diseases and cancers with deregulated Akt activation. Unraveling the molecular mechanisms for Akt signaling networks paves the way for developing selective inhibitors targeting Akt and its signaling regulation for the management of human diseases including cancer.
AB - Growth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its deregulation has been linked to various human diseases. Akt kinase is a central player transmitting extracellular clues to various cellular compartments, in turn executing these biological processes. Since the discovery of Akt three decades ago, the tremendous progress towards identifying its upstream regulators and downstream effectors and its roles in cancer has been made, offering novel paradigms and therapeutic strategies for targeting human diseases and cancers with deregulated Akt activation. Unraveling the molecular mechanisms for Akt signaling networks paves the way for developing selective inhibitors targeting Akt and its signaling regulation for the management of human diseases including cancer.
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U2 - 10.1186/s12929-022-00860-9
DO - 10.1186/s12929-022-00860-9
M3 - Review article
C2 - 36180910
AN - SCOPUS:85139215667
SN - 1021-7770
VL - 29
JO - Journal of Biomedical Science
JF - Journal of Biomedical Science
IS - 1
M1 - 76
ER -