Alendronate adherence and its impact on hip-fracture risk in patients with established osteoporosis in Taiwan

T. C. Lin, C. Y. Yang, Y. H. Kao Yang, S. J. Lin

研究成果: Article同行評審

28 引文 斯高帕斯(Scopus)

摘要

A pharmacoepidemiology study was conducted using the health insurance database in Taiwan to assess compliance with osteoporosis drug regimens and the impact of compliance on the risk for secondary fractures. Patients 50 years of age with vertebral/hip fracture who had been started on alendronate therapy for the first time only after the fracture were included. Compliance was measured using the medication possession ratio (MPR) and was included as a time-dependent covariate in the Cox model to compare the difference between compliant (MPR 80%) and noncompliant patients (MPR 80%) with respect to risk for subsequent hip fractures. Only 38% of the study population remained compliant during the first year of treatment. Over the 4-year follow-up period, the risk of hip fracture among the compliant patients was 70% lower than that among the noncompliant ones (adjusted hazard ratio (HR) 0.30). Among patients with osteoporosis in Taiwan who had experienced a fracture and had started alendronate therapy, compliance with the dosage regimen was suboptimal. It was also found that compliance significantly reduced the risk of secondary hip fracture up to 4 years.

原文English
頁(從 - 到)109-116
頁數8
期刊Clinical Pharmacology and Therapeutics
90
發行號1
DOIs
出版狀態Published - 2011 七月 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

指紋 深入研究「Alendronate adherence and its impact on hip-fracture risk in patients with established osteoporosis in Taiwan」主題。共同形成了獨特的指紋。

引用此