Alkyl chain-grafted poly(l -lysine) vesicles with tunable molecular assembly and membrane permeability

Bo Yu Chen, Yi Fong Huang, Yun Chiao Huang, Tain Ching Wen, Jeng Shiung Jan

研究成果: Article同行評審

28 引文 斯高帕斯(Scopus)

摘要

The preparation of alkyl chain-grafted poly(l-lysine) (PLL) vesicles with tunable molecular assembly in aqueous solution and the evaluation of their membrane permeability by drug release experiments have been investigated. Upon grafting long alkyl chains, polypeptides confined in the assembled nanostructures adopted ordered conformations such as α-helices or β-sheets/turns, leading to the dense packing of membranes and, consequently, the decreases in vesicular size and membrane permeability. The vesicles can also be cross-linked by genipin to form stable structures with tunable membrane permeability. Additionally, these vesicles exhibited noticeable pH-sensitive behavior, depending on the grafted alkyl chain and cross-linking.

原文English
頁(從 - 到)220-223
頁數4
期刊ACS Macro Letters
3
發行號3
DOIs
出版狀態Published - 2014 三月 18

All Science Journal Classification (ASJC) codes

  • 有機化學
  • 聚合物和塑料
  • 無機化學
  • 材料化學

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