Allergies and Risk of Head and Neck Cancer: An Original Study plus Meta-Analysis

Jenn Ren Hsiao, Chun Yen Ou, Hung I. Lo, Cheng Chih Huang, Wei Ting Lee, Jehn Shyun Huang, Ken Chung Chen, Tung Yiu Wong, Sen Tien Tsai, Chia Jui Yen, Yuan Hua Wu, Wei Ting Hsueh, Ming Wei Yang, Shang Yin Wu, Jang Yang Chang, Kwang Yu Chang, Chen Lin Lin, Fang Ting Wang, Yi Hui Wang, Ya Ling WengHan Chien Yang, Jeffrey S. Chang

研究成果: Article

14 引文 (Scopus)

摘要

Background: Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental risk factors, including consumption of alcohol, betel quid, and cigarette. Methods: The current paper reports results from: 1) an original hospital-based case-control study, which included 252 incident cases of HNC and 236 controls frequency-matched to cases on sex and age; and 2) a meta-analysis combining the results of the current case-control study and 13 previously published studies (9 cohort studies with 727,569 subjects and 550 HNC outcomes and 5 case-control studies with 4,017 HNC cases and 10,928 controls). Results: In the original case-control study, we observed a strong inverse association between allergies and HNC [odds ratio = 0.41, 95% confidence interval (CI): 0.27-0.62]. The meta-analysis also indicated a statistically significant inverse association between HNC and allergies [meta-relative risk (RR) = 0.76, 95% CI: 0.63-0.91], particularly strong for allergic rhinitis (meta-RR = 0.55, 95% CI: 0.40-0.76). In addition, the inverse association between allergies and HNC was observed only among men (meta-RR = 0.67, 95% CI: 0.54-0.84) but not among women (meta-RR = 0.98, 95% CI: 0.81-1.18). Conclusions: These findings suggest that immunity plays an influential role in the risk of HNC. Future studies investigating immune biomarkers, including cytokine profiles and genetic polymorphisms, are warranted to further delineate the relationship between allergies and HNC. Understanding the relationship between allergies and HNC may help devise effective strategies to reduce and treat HNC.

原文English
文章編號e55138
期刊PloS one
8
發行號2
DOIs
出版狀態Published - 2013 二月 1

指紋

Allergies
Head and Neck Neoplasms
meta-analysis
hypersensitivity
Meta-Analysis
Hypersensitivity
confidence interval
relative risk
case-control studies
Confidence Intervals
Case-Control Studies
Association reactions
head and neck neoplasms
Biomarkers
Polymorphism
Tobacco Products
betel
rhinitis
cigarettes
Alcohols

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

引用此文

@article{cdf843d5ff0a4ee2b05dcacd4e5a550b,
title = "Allergies and Risk of Head and Neck Cancer: An Original Study plus Meta-Analysis",
abstract = "Background: Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental risk factors, including consumption of alcohol, betel quid, and cigarette. Methods: The current paper reports results from: 1) an original hospital-based case-control study, which included 252 incident cases of HNC and 236 controls frequency-matched to cases on sex and age; and 2) a meta-analysis combining the results of the current case-control study and 13 previously published studies (9 cohort studies with 727,569 subjects and 550 HNC outcomes and 5 case-control studies with 4,017 HNC cases and 10,928 controls). Results: In the original case-control study, we observed a strong inverse association between allergies and HNC [odds ratio = 0.41, 95{\%} confidence interval (CI): 0.27-0.62]. The meta-analysis also indicated a statistically significant inverse association between HNC and allergies [meta-relative risk (RR) = 0.76, 95{\%} CI: 0.63-0.91], particularly strong for allergic rhinitis (meta-RR = 0.55, 95{\%} CI: 0.40-0.76). In addition, the inverse association between allergies and HNC was observed only among men (meta-RR = 0.67, 95{\%} CI: 0.54-0.84) but not among women (meta-RR = 0.98, 95{\%} CI: 0.81-1.18). Conclusions: These findings suggest that immunity plays an influential role in the risk of HNC. Future studies investigating immune biomarkers, including cytokine profiles and genetic polymorphisms, are warranted to further delineate the relationship between allergies and HNC. Understanding the relationship between allergies and HNC may help devise effective strategies to reduce and treat HNC.",
author = "Hsiao, {Jenn Ren} and Ou, {Chun Yen} and Lo, {Hung I.} and Huang, {Cheng Chih} and Lee, {Wei Ting} and Huang, {Jehn Shyun} and Chen, {Ken Chung} and Wong, {Tung Yiu} and Tsai, {Sen Tien} and Yen, {Chia Jui} and Wu, {Yuan Hua} and Hsueh, {Wei Ting} and Yang, {Ming Wei} and Wu, {Shang Yin} and Chang, {Jang Yang} and Chang, {Kwang Yu} and Lin, {Chen Lin} and Wang, {Fang Ting} and Wang, {Yi Hui} and Weng, {Ya Ling} and Yang, {Han Chien} and Chang, {Jeffrey S.}",
year = "2013",
month = "2",
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Allergies and Risk of Head and Neck Cancer : An Original Study plus Meta-Analysis. / Hsiao, Jenn Ren; Ou, Chun Yen; Lo, Hung I.; Huang, Cheng Chih; Lee, Wei Ting; Huang, Jehn Shyun; Chen, Ken Chung; Wong, Tung Yiu; Tsai, Sen Tien; Yen, Chia Jui; Wu, Yuan Hua; Hsueh, Wei Ting; Yang, Ming Wei; Wu, Shang Yin; Chang, Jang Yang; Chang, Kwang Yu; Lin, Chen Lin; Wang, Fang Ting; Wang, Yi Hui; Weng, Ya Ling; Yang, Han Chien; Chang, Jeffrey S.

於: PloS one, 卷 8, 編號 2, e55138, 01.02.2013.

研究成果: Article

TY - JOUR

T1 - Allergies and Risk of Head and Neck Cancer

T2 - An Original Study plus Meta-Analysis

AU - Hsiao, Jenn Ren

AU - Ou, Chun Yen

AU - Lo, Hung I.

AU - Huang, Cheng Chih

AU - Lee, Wei Ting

AU - Huang, Jehn Shyun

AU - Chen, Ken Chung

AU - Wong, Tung Yiu

AU - Tsai, Sen Tien

AU - Yen, Chia Jui

AU - Wu, Yuan Hua

AU - Hsueh, Wei Ting

AU - Yang, Ming Wei

AU - Wu, Shang Yin

AU - Chang, Jang Yang

AU - Chang, Kwang Yu

AU - Lin, Chen Lin

AU - Wang, Fang Ting

AU - Wang, Yi Hui

AU - Weng, Ya Ling

AU - Yang, Han Chien

AU - Chang, Jeffrey S.

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Background: Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental risk factors, including consumption of alcohol, betel quid, and cigarette. Methods: The current paper reports results from: 1) an original hospital-based case-control study, which included 252 incident cases of HNC and 236 controls frequency-matched to cases on sex and age; and 2) a meta-analysis combining the results of the current case-control study and 13 previously published studies (9 cohort studies with 727,569 subjects and 550 HNC outcomes and 5 case-control studies with 4,017 HNC cases and 10,928 controls). Results: In the original case-control study, we observed a strong inverse association between allergies and HNC [odds ratio = 0.41, 95% confidence interval (CI): 0.27-0.62]. The meta-analysis also indicated a statistically significant inverse association between HNC and allergies [meta-relative risk (RR) = 0.76, 95% CI: 0.63-0.91], particularly strong for allergic rhinitis (meta-RR = 0.55, 95% CI: 0.40-0.76). In addition, the inverse association between allergies and HNC was observed only among men (meta-RR = 0.67, 95% CI: 0.54-0.84) but not among women (meta-RR = 0.98, 95% CI: 0.81-1.18). Conclusions: These findings suggest that immunity plays an influential role in the risk of HNC. Future studies investigating immune biomarkers, including cytokine profiles and genetic polymorphisms, are warranted to further delineate the relationship between allergies and HNC. Understanding the relationship between allergies and HNC may help devise effective strategies to reduce and treat HNC.

AB - Background: Although the relationship between allergy and cancer has been investigated extensively, the role of allergy in head and neck cancer (HNC) appears less consistent. It is not clear whether allergies can independently influence the risk of HNC in the presence of known strong environmental risk factors, including consumption of alcohol, betel quid, and cigarette. Methods: The current paper reports results from: 1) an original hospital-based case-control study, which included 252 incident cases of HNC and 236 controls frequency-matched to cases on sex and age; and 2) a meta-analysis combining the results of the current case-control study and 13 previously published studies (9 cohort studies with 727,569 subjects and 550 HNC outcomes and 5 case-control studies with 4,017 HNC cases and 10,928 controls). Results: In the original case-control study, we observed a strong inverse association between allergies and HNC [odds ratio = 0.41, 95% confidence interval (CI): 0.27-0.62]. The meta-analysis also indicated a statistically significant inverse association between HNC and allergies [meta-relative risk (RR) = 0.76, 95% CI: 0.63-0.91], particularly strong for allergic rhinitis (meta-RR = 0.55, 95% CI: 0.40-0.76). In addition, the inverse association between allergies and HNC was observed only among men (meta-RR = 0.67, 95% CI: 0.54-0.84) but not among women (meta-RR = 0.98, 95% CI: 0.81-1.18). Conclusions: These findings suggest that immunity plays an influential role in the risk of HNC. Future studies investigating immune biomarkers, including cytokine profiles and genetic polymorphisms, are warranted to further delineate the relationship between allergies and HNC. Understanding the relationship between allergies and HNC may help devise effective strategies to reduce and treat HNC.

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DO - 10.1371/journal.pone.0055138

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