Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer

Hsiao Chen Liao, Shang-Yin Wu, Chun-Yen Ou, Jenn-Ren Hsiao, Jehn-Shun Huang, Sen-Tien Tsai, Cheng-Chih Huang, Dung-Yau Wang, Wei-Ting Lee, Ken-Chung Chen, Sheen-Yie Fang, Jiunn-Liang Wu, Tze-Ta Huang, Yuan-Hua Wu, Wei-Ting Hsueh, Chia-Jui Yen, Ming-Wei Yang, Forn-Chia Lin, Yu-Hsuan Lai, Jang-Yang ChangChen Lin Lin, Yi Hui Wang, Ya Ling Weng, Han Chien Yang, Yu Shan Chen, Jeffrey S. Chang

研究成果: Article

2 引文 (Scopus)

摘要

Purpose: Allergy symptoms have been associated with a reduced head and neck cancer (HNC) risk, while elevated blood immunoglobulin E (IgE) levels have been associated with an increased HNC risk. According to the “prophylaxis hypothesis,” allergic reaction is the body’s way of expelling carcinogens. IgE level may be increased by exposure to environmental carcinogens, including alcohol and cigarette smoke. We hypothesized that individuals with elevated serum IgE without allergy symptoms (i.e., asymptomatic atopic) would have the highest HNC risk. Methods: A case–control study of HNC (576 cases and 740 controls) was conducted to evaluate the association between allergy symptoms or serum total IgE and HNC risk and the effect modification of allergy symptoms on the association between serum total IgE and HNC risk. Results: Elevated serum total IgE was associated with a significantly increased HNC risk [odds ratio (OR) 1.71, 95 % confidence interval (CI) 1.21–2.42]. Having allergy symptoms was associated with a significantly reduced HNC risk (OR 0.56, 95 % CI 0.43–0.73). Compared to subjects with normal serum total IgE and no allergy symptoms, asymptomatic atopic individuals had a significantly increased HNC risk (OR 2.12, 95 % CI 1.33–3.35). Conclusions: Our results provided further evidence to support the “prophylaxis hypothesis.” Further investigations regarding the immune profiles of asymptomatic atopic individuals may provide additional clues for the biological mechanisms underlying the association between allergy symptoms, IgE, and HNC risk.

原文English
頁(從 - 到)1105-1115
頁數11
期刊Cancer Causes and Control
27
發行號9
DOIs
出版狀態Published - 2016 九月 1

指紋

Head and Neck Neoplasms
Immunoglobulin E
Hypersensitivity
Serum
Odds Ratio
Confidence Intervals
Environmental Carcinogens
Smoke
Tobacco Products
Carcinogens
Alcohols

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

引用此文

@article{c047344fdc034411901c1038df8d004b,
title = "Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer",
abstract = "Purpose: Allergy symptoms have been associated with a reduced head and neck cancer (HNC) risk, while elevated blood immunoglobulin E (IgE) levels have been associated with an increased HNC risk. According to the “prophylaxis hypothesis,” allergic reaction is the body’s way of expelling carcinogens. IgE level may be increased by exposure to environmental carcinogens, including alcohol and cigarette smoke. We hypothesized that individuals with elevated serum IgE without allergy symptoms (i.e., asymptomatic atopic) would have the highest HNC risk. Methods: A case–control study of HNC (576 cases and 740 controls) was conducted to evaluate the association between allergy symptoms or serum total IgE and HNC risk and the effect modification of allergy symptoms on the association between serum total IgE and HNC risk. Results: Elevated serum total IgE was associated with a significantly increased HNC risk [odds ratio (OR) 1.71, 95 {\%} confidence interval (CI) 1.21–2.42]. Having allergy symptoms was associated with a significantly reduced HNC risk (OR 0.56, 95 {\%} CI 0.43–0.73). Compared to subjects with normal serum total IgE and no allergy symptoms, asymptomatic atopic individuals had a significantly increased HNC risk (OR 2.12, 95 {\%} CI 1.33–3.35). Conclusions: Our results provided further evidence to support the “prophylaxis hypothesis.” Further investigations regarding the immune profiles of asymptomatic atopic individuals may provide additional clues for the biological mechanisms underlying the association between allergy symptoms, IgE, and HNC risk.",
author = "Liao, {Hsiao Chen} and Shang-Yin Wu and Chun-Yen Ou and Jenn-Ren Hsiao and Jehn-Shun Huang and Sen-Tien Tsai and Cheng-Chih Huang and Dung-Yau Wang and Wei-Ting Lee and Ken-Chung Chen and Sheen-Yie Fang and Jiunn-Liang Wu and Tze-Ta Huang and Yuan-Hua Wu and Wei-Ting Hsueh and Chia-Jui Yen and Ming-Wei Yang and Forn-Chia Lin and Yu-Hsuan Lai and Jang-Yang Chang and Lin, {Chen Lin} and Wang, {Yi Hui} and Weng, {Ya Ling} and Yang, {Han Chien} and Chen, {Yu Shan} and Chang, {Jeffrey S.}",
year = "2016",
month = "9",
day = "1",
doi = "10.1007/s10552-016-0788-4",
language = "English",
volume = "27",
pages = "1105--1115",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "9",

}

TY - JOUR

T1 - Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer

AU - Liao, Hsiao Chen

AU - Wu, Shang-Yin

AU - Ou, Chun-Yen

AU - Hsiao, Jenn-Ren

AU - Huang, Jehn-Shun

AU - Tsai, Sen-Tien

AU - Huang, Cheng-Chih

AU - Wang, Dung-Yau

AU - Lee, Wei-Ting

AU - Chen, Ken-Chung

AU - Fang, Sheen-Yie

AU - Wu, Jiunn-Liang

AU - Huang, Tze-Ta

AU - Wu, Yuan-Hua

AU - Hsueh, Wei-Ting

AU - Yen, Chia-Jui

AU - Yang, Ming-Wei

AU - Lin, Forn-Chia

AU - Lai, Yu-Hsuan

AU - Chang, Jang-Yang

AU - Lin, Chen Lin

AU - Wang, Yi Hui

AU - Weng, Ya Ling

AU - Yang, Han Chien

AU - Chen, Yu Shan

AU - Chang, Jeffrey S.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Purpose: Allergy symptoms have been associated with a reduced head and neck cancer (HNC) risk, while elevated blood immunoglobulin E (IgE) levels have been associated with an increased HNC risk. According to the “prophylaxis hypothesis,” allergic reaction is the body’s way of expelling carcinogens. IgE level may be increased by exposure to environmental carcinogens, including alcohol and cigarette smoke. We hypothesized that individuals with elevated serum IgE without allergy symptoms (i.e., asymptomatic atopic) would have the highest HNC risk. Methods: A case–control study of HNC (576 cases and 740 controls) was conducted to evaluate the association between allergy symptoms or serum total IgE and HNC risk and the effect modification of allergy symptoms on the association between serum total IgE and HNC risk. Results: Elevated serum total IgE was associated with a significantly increased HNC risk [odds ratio (OR) 1.71, 95 % confidence interval (CI) 1.21–2.42]. Having allergy symptoms was associated with a significantly reduced HNC risk (OR 0.56, 95 % CI 0.43–0.73). Compared to subjects with normal serum total IgE and no allergy symptoms, asymptomatic atopic individuals had a significantly increased HNC risk (OR 2.12, 95 % CI 1.33–3.35). Conclusions: Our results provided further evidence to support the “prophylaxis hypothesis.” Further investigations regarding the immune profiles of asymptomatic atopic individuals may provide additional clues for the biological mechanisms underlying the association between allergy symptoms, IgE, and HNC risk.

AB - Purpose: Allergy symptoms have been associated with a reduced head and neck cancer (HNC) risk, while elevated blood immunoglobulin E (IgE) levels have been associated with an increased HNC risk. According to the “prophylaxis hypothesis,” allergic reaction is the body’s way of expelling carcinogens. IgE level may be increased by exposure to environmental carcinogens, including alcohol and cigarette smoke. We hypothesized that individuals with elevated serum IgE without allergy symptoms (i.e., asymptomatic atopic) would have the highest HNC risk. Methods: A case–control study of HNC (576 cases and 740 controls) was conducted to evaluate the association between allergy symptoms or serum total IgE and HNC risk and the effect modification of allergy symptoms on the association between serum total IgE and HNC risk. Results: Elevated serum total IgE was associated with a significantly increased HNC risk [odds ratio (OR) 1.71, 95 % confidence interval (CI) 1.21–2.42]. Having allergy symptoms was associated with a significantly reduced HNC risk (OR 0.56, 95 % CI 0.43–0.73). Compared to subjects with normal serum total IgE and no allergy symptoms, asymptomatic atopic individuals had a significantly increased HNC risk (OR 2.12, 95 % CI 1.33–3.35). Conclusions: Our results provided further evidence to support the “prophylaxis hypothesis.” Further investigations regarding the immune profiles of asymptomatic atopic individuals may provide additional clues for the biological mechanisms underlying the association between allergy symptoms, IgE, and HNC risk.

UR - http://www.scopus.com/inward/record.url?scp=84979255329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979255329&partnerID=8YFLogxK

U2 - 10.1007/s10552-016-0788-4

DO - 10.1007/s10552-016-0788-4

M3 - Article

C2 - 27443169

AN - SCOPUS:84979255329

VL - 27

SP - 1105

EP - 1115

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 9

ER -