Alloantibody and xenoantibody cross-reactivity in transplantation

D. K.C. Cooper, Yau-Lin Tseng, S. L. Saidman

研究成果: Review article

50 引文 (Scopus)

摘要

The recent availability of pigs homozygous for α 1,3-galactosyltransferase gene knockout, and improved immunosuppressive regimens that prevent an elicited antibody response, are expected to contribute to significantly increased survival of pig organs transplanted into primates, bringing clinical trials of xenotransplantation closer. Patients highly sensitized to human leukocyte antigens, who may be precluded from obtaining a human donor organ, would be one group that might benefit from xenotransplantation. However, there have been few studies on whether there is cross-reactivity of anti-human leukocyte antigen antibodies with pig antigens. What data there are suggest that such cross-reactivity exists and that this may be detrimental to the outcome after transplantation of a pig organ. Neither is it known whether sensitization after a pig xenograft would preclude subsequent allotransplantation, although the data available suggest that this will not be the case. Further investigation on allo- and xenoantibody cross-reactivity is required.

原文English
頁(從 - 到)1-5
頁數5
期刊Transplantation
77
發行號1
DOIs
出版狀態Published - 2004 一月 15

指紋

Heterophile Antibodies
Isoantibodies
Swine
Transplantation
Heterologous Transplantation
HLA Antigens
Galactosyltransferases
Tissue Survival
Gene Knockout Techniques
Immunosuppressive Agents
Heterografts
Primates
Antibody Formation
Tissue Donors
Clinical Trials
Antigens
Antibodies

All Science Journal Classification (ASJC) codes

  • Transplantation

引用此文

Cooper, D. K.C. ; Tseng, Yau-Lin ; Saidman, S. L. / Alloantibody and xenoantibody cross-reactivity in transplantation. 於: Transplantation. 2004 ; 卷 77, 編號 1. 頁 1-5.
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Alloantibody and xenoantibody cross-reactivity in transplantation. / Cooper, D. K.C.; Tseng, Yau-Lin; Saidman, S. L.

於: Transplantation, 卷 77, 編號 1, 15.01.2004, p. 1-5.

研究成果: Review article

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