Alpha-Mangostin Reduces Pericellular Fibronectin on Suspended Tumor Cells and Therapeutically, but Not Prophylactically, Suppresses Distant Metastasis

Li Tzu Huang, Chin Ho Kuo, Lin Tseng, Yi Syuan Li, Li Hsin Cheng, Chin Yun Cheng, Shane Rong Sheu, Wen Tsan Chang, Chien Chin Chen, Hung Chi Cheng

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Major cancer deaths can be ascribed to distant metastasis to which the assembly of pericellular fibronectin (periFN) on suspended tumor cells (STCs) in the bloodstream that facilitate endothelial attachment can lead. Even though mangosteen pericarps (MP) extracts and the major component α-mangostin (α-MG) exhibit potent cancer chemopreventive properties, whether they can prophylactically and therapeutically be used as dietary nutraceuticals to prevent distant metastasis by suppressing periFN assembly on STCs within the circulation remains obscure. Immunofluorescence staining, MTT assays, flow cytometric assays, immunoblotting, and experimental metastasis mouse models were used to detect the effects of MP extracts or α-MG on periFN on STCs, tumor cell proliferation and apoptosis, the AKT activity, and tumor lung metastasis. The periFN assembly on STCs was significantly diminished upon treatments of STCs with either α-MG or MP extracts in a dose-dependent manner without inhibiting cell proliferation and viability due to increased AKT activity. Pretreatment of STCs with α-MG appeared to suppress tumor lung metastasis and prolong mouse survival rates. Oral gavage with MP extracts could therapeutically, but not prophylactically, prevent lung metastasis of STCs. We concluded that MP extracts or the major component α-MG may therapeutically serve as a potent anti-metastatic nutraceutical.

原文English
文章編號1375
期刊Life
12
發行號9
DOIs
出版狀態Published - 2022 9月

All Science Journal Classification (ASJC) codes

  • 生態學、進化論、行為學與系統學
  • 一般生物化學,遺傳學和分子生物學
  • 空間與行星科學
  • 古生物學

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