Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy

Aswathy Ammothumkandy, Kristine Ravina, Victoria Wolseley, Alexandria N. Tartt, Pen Ning Yu, Luis Corona, Naibo Zhang, George Nune, Laura Kalayjian, J. John Mann, Gorazd B. Rosoklija, Victoria Arango, Andrew J. Dwork, Brian Lee, J. A.D. Smith, Dong Song, Theodore W. Berger, Christianne Heck, Robert H. Chow, Maura BoldriniCharles Y. Liu, Jonathan J. Russin, Michael A. Bonaguidi

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4 引文 斯高帕斯(Scopus)

摘要

The hippocampus is the most common seizure focus in people. In the hippocampus, aberrant neurogenesis plays a critical role in the initiation and progression of epilepsy in rodent models, but it is unknown whether this also holds true in humans. To address this question, we used immunofluorescence on control healthy hippocampus and surgical resections from mesial temporal lobe epilepsy (MTLE), plus neural stem-cell cultures and multi-electrode recordings of ex vivo hippocampal slices. We found that a longer duration of epilepsy is associated with a sharp decline in neuronal production and persistent numbers in astrogenesis. Further, immature neurons in MTLE are mostly inactive, and are not observed in cases with local epileptiform-like activity. However, immature astroglia are present in every MTLE case and their location and activity are dependent on epileptiform-like activity. Immature astroglia, rather than newborn neurons, therefore represent a potential target to continually modulate adult human neuronal hyperactivity.

原文English
頁(從 - 到)493-503
頁數11
期刊Nature Neuroscience
25
發行號4
DOIs
出版狀態Published - 2022 4月

All Science Journal Classification (ASJC) codes

  • 神經科學 (全部)

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