An aptamer interacting with heat shock protein 70 shows therapeutic effects and prognostic ability in serous ovarian cancer

Chang Ni Lin, Yi Cheng Tsai, Ching Cheng Hsu, Yu Ling Liang, Yi Ying Wu, Chieh Yi Kang, Chun Hong Lin, Pang Hung Hsu, Gwo Bin Lee, Keng Fu Hsu

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Lin et al. demonstrated that Tx-01 plays a therapeutic role through interfering intracellular HSP70/NICD interaction to reduce nuclear translocation. Tx-01 also interacts with membrane-bound HSP70 (mHSP70) recognized by ascitic NK cells and acts as a favorable prognostic marker in serous ovarian cancer.

原文English
頁(從 - 到)757-768
頁數12
期刊Molecular Therapy - Nucleic Acids
23
DOIs
出版狀態Published - 2021 3月 5

All Science Journal Classification (ASJC) codes

  • 分子醫學
  • 藥物發現

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