An association study of interleukin-4 gene and preeclampsia in Taiwan

Lin Kang, Chung Hwan Chen, Chen Hsiang Yu, Chiung Hsin Chang, Fong Ming Chang

研究成果: Article

8 引文 斯高帕斯(Scopus)

摘要

Objective: To test whether the interleukin-4 (IL-4) gene polymorphisms could be used as markers of susceptibility for preeclampsia in Taiwan. Materials and methods: This study included 78 women with preeclampsia and 125 normal controls. A polymerase chain reaction was used to analyze the variable number of tandem repeats polymorphism for the IL-4 gene intron 3. Restriction fragment length polymorphism analysis using endonuclease BsmFI was performed for the IL-4 gene at the promoter-590 position. The association between the genotype and disease was examined using Chi-square tests. Results: We found no significant differences in the genotype distributions and allele frequencies for the IL-4 gene at both promoter and intron 3 regions between the preeclampsia and control groups. Conclusion: Even though this is the first study investigating the association between the promoter region and intron 3 polymorphisms of IL-4 and preeclampsia worldwide, our data do not support a role of the IL-4 gene in the pathogenesis of preeclampsia in Taiwanese women.

原文English
頁(從 - 到)215-219
頁數5
期刊Taiwanese Journal of Obstetrics and Gynecology
53
發行號2
DOIs
出版狀態Published - 2014 六月

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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