An efficient synthesis of a potent anti-inflammatory agent, viscolin, and its inducible nitric oxide synthase inhibitory activity

Ping Chung Kuo, Yi Hsien Chen, Yann Lii Leu, Chieh Hung Huang, Yu Ren Liao, E. Jian Lee, Mei Lin Yang, Tian Shung Wu

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

A new and efficient synthetic pathway employed the aldol condensation between the acetophenone (3) and vanillin derivative (4) resulted in the precursor chalcone intermediate (14). The target compound viscolin (1) could be afforded through the hydrogenation of the chalcone and followed by deprotection. The present strategy described the development of a more efficient procedure that allowed large-scale production of viscolin for the further research of biological activity both in vitro and in vivo.

原文English
頁(從 - 到)557-561
頁數5
期刊Chemical and Pharmaceutical Bulletin
60
發行號4
DOIs
出版狀態Published - 2012 四月

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 藥物發現

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