An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection

Tsung Ting Tsai, Yi Jui Chuang, Yee Shin Lin, Shu Wen Wan, Chia Ling Chen, Chiou Feng Lin

研究成果: Review article同行評審

36 引文 斯高帕斯(Scopus)

摘要

Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms for DENV are complicated, involving viral cytotoxicity, immunopathogenesis, autoimmunity, and underlying host diseases. Viral load correlates with disease severity, while the antibody-dependent enhancement of infection largely determines the secondary effects of DENV infection. Epidemiological and experimental studies have revealed an association between the plasma levels of interleukin (IL)-10, which is the master anti-inflammatory cytokine, and disease severity in patients with DENV infection. Based on current knowledge of IL-10-mediated immune regulation during infection, researchers speculate an emerging role for IL-10 in clinical disease prognosis and dengue pathogenesis. However, the regulation of dengue pathogenesis has not been fully elucidated. This review article discusses the regulation and implications of IL-10 in DENV infection. For future strategies against DENV infection, manipulating IL-10 may be an effective antiviral treatment in addition to the development of a safe dengue vaccine.

原文English
文章編號40
期刊Journal of biomedical science
20
發行號1
DOIs
出版狀態Published - 2013

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

指紋 深入研究「An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection」主題。共同形成了獨特的指紋。

引用此