TY - JOUR
T1 - An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection
AU - Tsai, Tsung Ting
AU - Chuang, Yi Jui
AU - Lin, Yee Shin
AU - Wan, Shu Wen
AU - Chen, Chia Ling
AU - Lin, Chiou Feng
N1 - Funding Information:
We apologize to colleagues whose relevant contributions were not cited due to space limitations. This work was supported by grants from the National Health Research Institutes (NHRI-EX101-9917NC) and the National Science Council (NSC101-2321-B-006-029), Taiwan.
PY - 2013
Y1 - 2013
N2 - Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms for DENV are complicated, involving viral cytotoxicity, immunopathogenesis, autoimmunity, and underlying host diseases. Viral load correlates with disease severity, while the antibody-dependent enhancement of infection largely determines the secondary effects of DENV infection. Epidemiological and experimental studies have revealed an association between the plasma levels of interleukin (IL)-10, which is the master anti-inflammatory cytokine, and disease severity in patients with DENV infection. Based on current knowledge of IL-10-mediated immune regulation during infection, researchers speculate an emerging role for IL-10 in clinical disease prognosis and dengue pathogenesis. However, the regulation of dengue pathogenesis has not been fully elucidated. This review article discusses the regulation and implications of IL-10 in DENV infection. For future strategies against DENV infection, manipulating IL-10 may be an effective antiviral treatment in addition to the development of a safe dengue vaccine.
AB - Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms for DENV are complicated, involving viral cytotoxicity, immunopathogenesis, autoimmunity, and underlying host diseases. Viral load correlates with disease severity, while the antibody-dependent enhancement of infection largely determines the secondary effects of DENV infection. Epidemiological and experimental studies have revealed an association between the plasma levels of interleukin (IL)-10, which is the master anti-inflammatory cytokine, and disease severity in patients with DENV infection. Based on current knowledge of IL-10-mediated immune regulation during infection, researchers speculate an emerging role for IL-10 in clinical disease prognosis and dengue pathogenesis. However, the regulation of dengue pathogenesis has not been fully elucidated. This review article discusses the regulation and implications of IL-10 in DENV infection. For future strategies against DENV infection, manipulating IL-10 may be an effective antiviral treatment in addition to the development of a safe dengue vaccine.
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U2 - 10.1186/1423-0127-20-40
DO - 10.1186/1423-0127-20-40
M3 - Review article
C2 - 23800014
AN - SCOPUS:84879209749
SN - 1021-7770
VL - 20
JO - Journal of biomedical science
JF - Journal of biomedical science
IS - 1
M1 - 40
ER -