TY - JOUR
T1 - An event-related potential and behavioral study of impaired inhibitory control in children with autism spectrum disorder
AU - Tsai, Chia Liang
AU - Pan, Chien Yu
AU - Wang, Chun Hao
AU - Tseng, Yu Ting
AU - Hsieh, Kai Wen
N1 - Funding Information:
The authors would like to gratefully acknowledge the participating families and all staff involved in this study. This research was also supported by a grant from the National Science Council ( NSC 98-2410-H-006-106-MY2 ) in Taiwan.
PY - 2011/7
Y1 - 2011/7
N2 - Autism spectrum disorders (ASD) are characterized by a deficit of dorsal visual stream processing as well as the impairment of inhibitory control capability. However, the cognitive processing mechanisms of executive dysfunction have not been addressed. In the present study, the endogenous Posner paradigm task was administered to 15 children with ASD and 16 typically developing (TD) children to simultaneously investigate and compare the behavioral performance and event-related potentials (ERPs) measures. Children with ASD showed slower reaction time in the incongruent condition but did not significantly differ in the overall conditions and in response accuracy as compared to TD children. The ASD group also exhibited significant impairment on measures of inhibitory control. In terms of ERPs regarding early and late inhibition, there were no significant differences found with regard to N2 latency, N2 amplitude, and P3 amplitude in children with ASD relative to TD children, but the ASD group manifested prolonged latency on the P3 component to target stimuli, especially in the incongruent condition, which is indicative of slow and inefficient stimulus classification speed as compared to TD children.
AB - Autism spectrum disorders (ASD) are characterized by a deficit of dorsal visual stream processing as well as the impairment of inhibitory control capability. However, the cognitive processing mechanisms of executive dysfunction have not been addressed. In the present study, the endogenous Posner paradigm task was administered to 15 children with ASD and 16 typically developing (TD) children to simultaneously investigate and compare the behavioral performance and event-related potentials (ERPs) measures. Children with ASD showed slower reaction time in the incongruent condition but did not significantly differ in the overall conditions and in response accuracy as compared to TD children. The ASD group also exhibited significant impairment on measures of inhibitory control. In terms of ERPs regarding early and late inhibition, there were no significant differences found with regard to N2 latency, N2 amplitude, and P3 amplitude in children with ASD relative to TD children, but the ASD group manifested prolonged latency on the P3 component to target stimuli, especially in the incongruent condition, which is indicative of slow and inefficient stimulus classification speed as compared to TD children.
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U2 - 10.1016/j.rasd.2010.12.004
DO - 10.1016/j.rasd.2010.12.004
M3 - Article
AN - SCOPUS:79952450020
SN - 1750-9467
VL - 5
SP - 1092
EP - 1102
JO - Research in Autism Spectrum Disorders
JF - Research in Autism Spectrum Disorders
IS - 3
ER -