An integrated microfluidic platform for cholangiocarcinoma diagnosis from clinical bile juice samples by utilizing multiple affinity reagents

Tsung Han Lu, Nai Jung Chiang, Chien Jui Huang, Priya Gopinathan, Hsiu Chi Tu, Yi Cheng Tsai, Yen Shen Shan, Shang Cheng Hung, Gwo Bin Lee

研究成果: Conference contribution

摘要

Cholangiocarcinoma (CCA) is a lethal disease owing to its difficulty to be diagnosed at early stages and lack of effective treatment. To improve the accuracy of early diagnosis of CCA, one of the promising approaches is to use CCA-specific affinity reagents to detect CCA cells by liquid biopsy. In this study, bile juice, a body fluid close to lesions, was used as a clinical sample for CCA cell isolation and detection. Moreover, a novel microfluidic chip was designed and fabricated to detect CCA cells in the bile juice by using three types of affinity reagents. Experimental results showed that the three affinity reagents could capture CCA tumor cells in patients' bile juice (with a volume of only 3 mL) within 120 min. This microfluidic system may serve as a promising tool for detecting CCA in clinical settings.

原文English
主出版物標題15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020
發行者Institute of Electrical and Electronics Engineers Inc.
頁面261-264
頁數4
ISBN(電子)9781728172309
DOIs
出版狀態Published - 2020 九月 27
事件15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020 - Virtual, San Diego, United States
持續時間: 2020 九月 272020 九月 30

出版系列

名字15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020

Conference

Conference15th IEEE International Conference on Nano/Micro Engineered and Molecular System, NEMS 2020
國家/地區United States
城市Virtual, San Diego
期間20-09-2720-09-30

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 分子生物學
  • 電化學
  • 生物醫學工程
  • 電子、光磁材料
  • 儀器

指紋

深入研究「An integrated microfluidic platform for cholangiocarcinoma diagnosis from clinical bile juice samples by utilizing multiple affinity reagents」主題。共同形成了獨特的指紋。

引用此