An integrated microfluidic system for rapid HbA1c measurement

Diabetes mellitus (DM) is one of the most prevalent diseases and easily lead to serious complications. Glycosylated hemoglobin (HbA1c), an emerging biomarker for reliable monitoring of DM is commonly detected by bench-top immunoassays, which are labor-intensive and time-consuming. As an advance to existing methods, a microfluidic platform capable of performing automated immunoassay for HbA1c detection within 25 minutes is presented in this work. The microfluidic assay was able to detect HbA1c from human whole blood samples and delivered similar performance as its bench-top counterpart. The developed microfluidic chip is therefore promising for rapid detection of HbA1c for monitoring DM.