@article{a4b093d95003478f89dd6b685949a0cf,
title = "An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples",
abstract = "Certain blood-borne biomarkers offer a potent methodology for understanding the risk of cardiovascular diseases (CVDs) with clinicians generally advocating the use of multiple biomarkers for proper risk assessment of CVDs. Herein four such CVDs biomarkers- C-reactive protein (CRP), N-terminal pro b-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), and fibrinogen- were rapidly (5 min) analyzed from clinical samples (~ 4 µL) on an integrated microfluidic platform equipped with 1) immobilized highly specific aptamer probes and 2) field-effect transistor (FET)-based sensor arrays. The calibration curve from the FET sensor arrays showed good agreement in the physiological concentration ranges for CRP (0.1–50 mg/L), NT-proBNP (50–10,000 pg/mL), cTnI (1–10,000 pg/mL), and fibrinogen (0.1–5 mg/mL). The developed prototype of this fully automated portable device requires minimal reagent and sample inputs and consequently shows great promise for next-generation point-of-care devices assaying multiple CVDs biomarkers in clinical samples.",
author = "Anirban Sinha and Tai, {Tse Yu} and Li, {Kuang Hsien} and Priya Gopinathan and Chung, {Yi Da} and Indu Sarangadharan and Ma, {Hsi Pin} and Huang, {Po Chiun} and Shiesh, {Shu Chu} and Wang, {Yu Lin} and Lee, {Gwo Bin}",
note = "Funding Information: The authors would like to thank the Ministry of Science and Technology ( MOST ) of Taiwan ( MOST 106-2221-E-007-001 and MOST 107-2221-E-007-013-MY3 to GBL) for funding this work. Partial financial support from the Ministry of Education of Taiwan{\textquoteright}s Higher Education Sprout Project (Grant no. 107Q2713E1 ) is also greatly appreciated. Funding Information: The authors would like to thank the Ministry of Science and Technology (MOST) of Taiwan (MOST 106-2221-E-007-001 and MOST 107-2221-E-007-013-MY3 to GBL) for funding this work. Partial financial support from the Ministry of Education of Taiwan's Higher Education Sprout Project (Grant no. 107Q2713E1) is also greatly appreciated. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",
year = "2019",
month = mar,
day = "15",
doi = "10.1016/j.bios.2019.01.001",
language = "English",
volume = "129",
pages = "155--163",
journal = "Biosensors and Bioelectronics",
issn = "0956-5663",
publisher = "Elsevier Limited",
}