Androgen excess down-regulates connexin43 in a human granulosa cell line

Cheng Hsuan Wu, Jyuer Ger Yang, Jiann Jou Yang, Yueh Min Lin, Hong Der Tsai, Ching Yuang Lin, Pao Lin Kuo

研究成果: Article同行評審

24 引文 斯高帕斯(Scopus)

摘要

By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients.

原文English
頁(從 - 到)2938-2941
頁數4
期刊Fertility and Sterility
94
發行號7
DOIs
出版狀態Published - 2010 十二月

All Science Journal Classification (ASJC) codes

  • 生殖醫學
  • 婦產科

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