Angiogenesis, thrombospondin-1 and cervical carcinogenesis

Ming Ping Wu, Cheng Yang Chou

研究成果: Review article同行評審

1 引文 斯高帕斯(Scopus)


Angiogenesis, the growth of new vessels from existing vasculature, plays an essential role in tumor development. The process involves interaction among cancer cells, endothelial cells, and components of the extracellular matrix, and is regulated by the balance of angiogenesis activators and angiogenesis inhibitors. This review profiles some fundamental concepts of angiogenesis, the importance of angiogenesis in cervical neoplasm, and the role of thrombospondin-1 as an angiogenesis inhibitor in cervical carcinogenesis. The usefulness and limitations of microvessel density in evaluation of angiogenic status are also discussed. Recent research and evolving concepts have led to a paradigm shift in anticancer therapy, from conventional cancer-centered chemotherapy to angiogenic or "metronomic" chemotherapy and/or combined angiogenesis inhibitors. The epigenetic strategy, which views the tumor system as a whole, transcends the cancer gene-centered approach.

頁(從 - 到)128-138
期刊Taiwanese Journal of Obstetrics and Gynecology
出版狀態Published - 2005 6月

All Science Journal Classification (ASJC) codes

  • 婦產科


深入研究「Angiogenesis, thrombospondin-1 and cervical carcinogenesis」主題。共同形成了獨特的指紋。