Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer

Yi Ting Chen; Chung Liang Ho; Po Ku Chen; Yuh Ling Chen; Chuan Fa Chang

doi:10.1016/j.canlet.2013.06.025

Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer

Yi Ting Chen, Chung Liang Ho, Po Ku Chen, Yuh Ling Chen, Chuan Fa Chang

研究成果: Article › 同行評審

22 引文斯高帕斯（Scopus）

摘要

The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.

原文	English
頁（從 - 到）	270-278
頁數	9
期刊	Cancer Letters
卷	339
發行號	2
DOIs	https://doi.org/10.1016/j.canlet.2013.06.025
出版狀態	Published - 2013 10月 10

All Science Journal Classification (ASJC) codes

腫瘤科
癌症研究

存取文件

10.1016/j.canlet.2013.06.025

其它文件與鏈接

引用此

@article{b7efc8edf3844554a82757ca3b1d0253,

title = "Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer",

abstract = "The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.",

author = "Chen, {Yi Ting} and Ho, {Chung Liang} and Chen, {Po Ku} and Chen, {Yuh Ling} and Chang, {Chuan Fa}",

note = "Funding Information: We are grateful for the support from the Tissue Bank and Bioinformatics Core Lab, Research Center of Clinical Medicine, National Cheng Kung University Hospital. Computational analyses and data mining were performed using the system provided by the Bioinformatics Core at the National Cheng Kung University. We are also grateful for the financial support from National Science Council Grant ( NSC 100-2321-B-006-009- , NSC 101-2321-B-006-008- ). ",

year = "2013",

month = oct,

day = "10",

doi = "10.1016/j.canlet.2013.06.025",

language = "English",

volume = "339",

pages = "270--278",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Anterior gradient 2

T2 - A novel sensitive tumor marker for metastatic oral cancer

AU - Chen, Yi Ting

AU - Ho, Chung Liang

AU - Chen, Po Ku

AU - Chen, Yuh Ling

AU - Chang, Chuan Fa

N1 - Funding Information: We are grateful for the support from the Tissue Bank and Bioinformatics Core Lab, Research Center of Clinical Medicine, National Cheng Kung University Hospital. Computational analyses and data mining were performed using the system provided by the Bioinformatics Core at the National Cheng Kung University. We are also grateful for the financial support from National Science Council Grant ( NSC 100-2321-B-006-009- , NSC 101-2321-B-006-008- ).

PY - 2013/10/10

Y1 - 2013/10/10

N2 - The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.

AB - The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.

UR - http://www.scopus.com/inward/record.url?scp=84883758354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883758354&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2013.06.025

DO - 10.1016/j.canlet.2013.06.025

M3 - Article

C2 - 23834814

AN - SCOPUS:84883758354

SN - 0304-3835

VL - 339

SP - 270

EP - 278

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer

摘要

All Science Journal Classification (ASJC) codes

存取文件

其它文件與鏈接

指紋

引用此