Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer

Yi Ting Chen, Chung Liang Ho, Po Ku Chen, Yuh Ling Chen, Chuan Fa Chang

研究成果: Article

12 引文 (Scopus)

摘要

The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.

原文English
頁(從 - 到)270-278
頁數9
期刊Cancer Letters
339
發行號2
DOIs
出版狀態Published - 2013 十月 10

指紋

Mouth Neoplasms
Tumor Biomarkers
Biomarkers
Neoplasm Metastasis
Gene Expression Profiling
Squamous Cell Carcinoma
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

引用此文

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abstract = "The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 ( agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.",
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Anterior gradient 2 : A novel sensitive tumor marker for metastatic oral cancer. / Chen, Yi Ting; Ho, Chung Liang; Chen, Po Ku; Chen, Yuh Ling; Chang, Chuan Fa.

於: Cancer Letters, 卷 339, 編號 2, 10.10.2013, p. 270-278.

研究成果: Article

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