Anti-IL-20 monoclonal antibody alleviates inflammation in oral cancer and suppresses tumor growth

Yu Hsiang Hsu, Chi Chen Wei, Dar Bin Shieh, Chien Hui Chan, Ming Shi Chang

研究成果: Article同行評審

23 引文 斯高帕斯(Scopus)

摘要

Interleukin-20 (IL-20) is a proinflammatory cytokine involved in rheumatoid arthritis, atherosclerosis, and osteoporosis. However, little is known about the role of IL-20 in oral cancer. We explored the function of IL-20 in the tumor progression of oral cancer. IL-20 expression levels in tumorous and nontumorous oral tissue specimens from 40 patients with four different stages oral cancer were analyzed with immunohistochemistry (IHC) staining and quantitative real-timePCR(qRT-PCR). Expression of IL-20 and its receptor subunits was higher in clinical oral tumor tissue than in nontumorous oral tissue. The role of IL-20 was examined in two oral cancer cell lines (OC-3 and OEC-M1). In vitro, IL-20 promoted TNF-α, IL-1β, MCP-1, CCR4, and CXCR4 and increased proliferation, migration, reactive oxygen species (ROS) production, and colony formation of oral cancer cells via activated STAT3 and AKT/JNK/ERK signals. To evaluate the therapeutic potential of anti-IL-20 monoclonal antibody 7E for treating oral cancer, an ex vivo tumor growth model was used. In vivo, 7E reduced tumor growth and inflammation in oral cancer cells. In conclusion, IL-20 promoted oral tumor growth, migration, and tumor-associated inflammation. Therefore, IL-20 may be a novel target for treating oral cancer, and anti-IL-20 monoclonal antibody 7E may be a feasible therapeutic.

原文English
頁(從 - 到)1430-1439
頁數10
期刊Molecular Cancer Research
10
發行號11
DOIs
出版狀態Published - 2012 十一月

All Science Journal Classification (ASJC) codes

  • 分子生物學
  • 腫瘤科
  • 癌症研究

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