Anti-inflammatory and neuroprotective constituents from the peels of citrus grandis

Ping Chung Kuo, Yu Ren Liao, Hsin Yi Hung, Chia Wei Chuang, Tsong Long Hwang, Shiow Chyn Huang, Young Ji Shiao, Daih Huang Kuo, Tian Shung Wu

研究成果: Article同行評審

28 引文 斯高帕斯(Scopus)

摘要

A series of chromatographic separations performed on the ethanol extracts of the peels of Citrus grandis has led to the characterization of forty compounds, including seventeen coumarins, eight flavonoids, two triterpenoids, four benzenoids, two steroids, one lignan, one amide, and five other compounds, respectively. The chemical structures of the purified constituents were identified on the basis of spectroscopic elucidation, including 1D- and 2D-NMR, UV, IR, and mass spectrometric analysis. Most of the isolated compounds were examined for their inhibition of superoxide anion generation and elastase release by human neutrophils. Among the isolates, isomeranzin (3), 17,18-dihydroxybergamottin (12), epoxybergamottin (13), rhoifolin (19), vitexicarpin (22) and 4-hydroxybenzaldehyde (29) displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values ranged from 0.54 to 7.57 µM, and 0.43 to 4.33 µM, respectively. In addition, 7-hydroxy-8-(2-hydroxy-3-methylbut-3-enyl)coumarin (8) and 17,18-dihydroxybergamottin (12) also exhibited the protection of neurons against Aβ-mediated neurotoxicity at 50 µM.

原文English
文章編號967
期刊Molecules
22
發行號6
DOIs
出版狀態Published - 2017 6月

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 化學(雜項)
  • 分子醫學
  • 藥學科學
  • 藥物發現
  • 物理與理論化學
  • 有機化學

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