Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Ping Chung Kuo; Hsin Yi Hung; Tsong Long Hwang; Wen Ke Du; Hsiang Chih Ku; E. Jian Lee; Shih Huang Tai; Fu An Chen; Tian Shung Wu

doi:10.1021/acs.jnatprod.7b00039

Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Ping Chung Kuo, Hsin Yi Hung, Tsong Long Hwang, Wen Ke Du, Hsiang Chih Ku, E. Jian Lee, Shih Huang Tai, Fu An Chen, Tian Shung Wu

研究成果: Article › 同行評審

7 引文斯高帕斯（Scopus）

摘要

Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.

原文	English
頁（從 - 到）	783-789
頁數	7
期刊	Journal of Natural Products
卷	80
發行號	4
DOIs	https://doi.org/10.1021/acs.jnatprod.7b00039
出版狀態	Published - 2017 四月 28

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

存取文件

10.1021/acs.jnatprod.7b00039

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引用此

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AU - Kuo, Ping Chung

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AU - Du, Wen Ke

AU - Ku, Hsiang Chih

AU - Lee, E. Jian

AU - Tai, Shih Huang

AU - Chen, Fu An

AU - Wu, Tian Shung

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