Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Ping Chung Kuo, Hsin Yi Hung, Tsong Long Hwang, Wen Ke Du, Hsiang Chih Ku, E. Jian Lee, Shih Huang Tai, Fu An Chen, Tian Shung Wu

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.

原文English
頁(從 - 到)783-789
頁數7
期刊Journal of Natural Products
80
發行號4
DOIs
出版狀態Published - 2017 四月 28

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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