Anti-inflammatory neolignans from the roots of Magnolia officinalis

Hung Cheng Shih, Ping Chung Kuo, Shwu Jen Wu, Tsong Long Hwang, Hsin Yi Hung, De Yang Shen, Po Chuen Shieh, Yu Ren Liao, E. Jian Lee, Qiong Gu, Kuo Hsiung Lee, Tian Shung Wu

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

Nine neolignan derivatives (1-9) were characterized from the roots of Magnolia officinalis, and their structures were elucidated based on spectroscopic and physicochemical analyses. Among them, houpulins E (1) and M (9) possess novel homo- and trinor-neolignan skeletons. In addition, 15 known compounds (10-24) were identified by comparison of their spectroscopic and physical data with those reported in the literature. Some of the purified constituents were examined for anti-inflammatory activity and, among the tested compounds, houpulins G (3), I (5), J (6), and 2,2'-dihydroxy-3-methoxy-5,5'-di-(2-propenylbiphenyl) (19) significantly inhibited superoxide anion generation and elastase release with IC50 values ranging from 3.54 to 5.48 μM and 2.16 to 3.39 μM, respectively. Therefore, these neolignan derivatives have tremendous potential to be explored as anti-inflammatory agents.

原文English
頁(從 - 到)1439-1445
頁數7
期刊Bioorganic and Medicinal Chemistry
24
發行號7
DOIs
出版狀態Published - 2016 4月 1

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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