Anti-inflammatory principles from Cordyceps sinensis

Mei Lin Yang, Ping Chung Kuo, Tsong Long Hwang, Tian Shung Wu

研究成果: Article同行評審

70 引文 斯高帕斯(Scopus)

摘要

In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has resulted in the identification of 50 compounds, including five constituents, cordysinins A-E (1-5), reported from a natural source for the first time. In addition, compounds were examined for their anti-inflammatory activity. 1-(5-Hydroxymethyl-2-furyl)-β-carboline displayed the most significant inhibition of superoxide anion generation and elastase release with IC 50 values of 0.45 ± 0.15 and 1.68 ± 0.32 μM, respectively.

原文English
頁(從 - 到)1996-2000
頁數5
期刊Journal of Natural Products
74
發行號9
DOIs
出版狀態Published - 2011 九月 23

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學

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