Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo, Yi Hung Wu, Hsin Yi Hung, Sio Hong Lam, Guo Hao Ma, Liang Mou Kuo, Tsong Long Hwang, Daih Huang Kuo, Tian Shung Wu

研究成果: Article


Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

期刊Bioorganic and Medicinal Chemistry Letters
出版狀態Published - 2020 七月 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

指紋 深入研究「Anti-inflammatory principles from Lindera aggregata」主題。共同形成了獨特的指紋。

  • 引用此