Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo, Yi Hung Wu, Hsin Yi Hung, Sio Hong Lam, Guo Hao Ma, Liang Mou Kuo, Tsong Long Hwang, Daih Huang Kuo, Tian Shung Wu

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

原文English
文章編號127224
期刊Bioorganic and Medicinal Chemistry Letters
30
發行號13
DOIs
出版狀態Published - 2020 七月 1

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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