Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo; Yi Hung Wu; Hsin Yi Hung; Sio Hong Lam; Guo Hao Ma; Liang Mou Kuo; Tsong Long Hwang; Daih Huang Kuo; Tian Shung Wu

doi:10.1016/j.bmcl.2020.127224

Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo, Yi Hung Wu, Hsin Yi Hung, Sio Hong Lam, Guo Hao Ma, Liang Mou Kuo, Tsong Long Hwang, Daih Huang Kuo, Tian Shung Wu

研究成果: Article › 同行評審

23 引文斯高帕斯（Scopus）

摘要

Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC₅₀ values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

原文	English
文章編號	127224
期刊	Bioorganic and Medicinal Chemistry Letters
卷	30
發行號	13
DOIs	https://doi.org/10.1016/j.bmcl.2020.127224
出版狀態	Published - 2020 7月 1

All Science Journal Classification (ASJC) codes

生物化學
分子醫學
分子生物學
藥學科學
藥物發現
臨床生物化學
有機化學

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10.1016/j.bmcl.2020.127224

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title = "Anti-inflammatory principles from Lindera aggregata",

abstract = "Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.",

author = "Kuo, {Ping Chung} and Wu, {Yi Hung} and Hung, {Hsin Yi} and Lam, {Sio Hong} and Ma, {Guo Hao} and Kuo, {Liang Mou} and Hwang, {Tsong Long} and Kuo, {Daih Huang} and Wu, {Tian Shung}",

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AU - Kuo, Ping Chung

AU - Wu, Yi Hung

AU - Hung, Hsin Yi

AU - Lam, Sio Hong

AU - Ma, Guo Hao

AU - Kuo, Liang Mou

AU - Hwang, Tsong Long

AU - Kuo, Daih Huang

AU - Wu, Tian Shung

PY - 2020/7/1

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Anti-inflammatory principles from Lindera aggregata

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