Anti-inflammatory principles from the needles of pinus taiwanensis hayata and in silico studies of their potential anti-aging effects

Ping Chung Kuo, Yue Chiun Li, Anjar M. Kusuma, Jason T.C. Tzen, Tsong Long Hwang, Guan Hong Ye, Mei Lin Yang, Sheng Yang Wang

研究成果: Article同行評審

摘要

Pinus needle tea are very popular in Eastern countries such as Japan, Russia, Korea, and China. Pine needle tea is claimed to have significant anti-aging effects, but no clear evidence has supported this until now. In the present study, five undescribed compounds (1–5) as well as seventy-two known compounds were purified and characterized from the bioactive fraction of methanol extracts of P. taiwanensis needles. Most of the isolates were examined for their anti-inflammatory bioactivity by cellular neutrophil model and six compounds (45, 47, 48, 49, 50, and 51) exhibited a significant inhibition on superoxide anion generation and elastase release with IC50 values ranging from 3.3 ± 0.9 to 8.3 ± 0.8 µM. These anti-inflammatory ingredients were subjected to docking computing to evaluate their binding affinity on the ghrelin receptor, which played an important role in regulating metabolism, with anti-aging effects. Compounds 49, 50, and 51 formed a stable complex with the ghrelin receptor via hydrogen bonds and different types of interactions. These results suggest the flavonoids are responsible for the potential anti-aging effects of pine needle tea.

原文English
文章編號598
期刊Antioxidants
10
發行號4
DOIs
出版狀態Published - 2021 四月

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

指紋 深入研究「Anti-inflammatory principles from the needles of pinus taiwanensis hayata and in silico studies of their potential anti-aging effects」主題。共同形成了獨特的指紋。

引用此