Anti-inflammatory principles from the stem and root barks of Citrus medica

Yu Yi Chan, Chan Hao Li, Yuh Chiang Shen, Tian Shung Wu

研究成果: Article同行評審

35 引文 斯高帕斯(Scopus)

摘要

Bioassay-guided investigation of the anti-inflammatory principles from the stem and root barks of Citrus medica L. var. sarcodactylis SWINGLE has led to the isolation of a new coumarin, namely citrumedin-B (1) and thirty known compounds. The anti-inflammatory components were xanthyletin (2), nordentatin (3), atalantoflavon (4) and lonchocarpol A (5) which displayed potent nitric oxide (NO)-reducing activity in microglial cells. The structure of this new compound was completely elucidated using a combination of 2D NMR techniques (correlation spectroscopy (COSY), nuclear Overhauser effect spectroscopy (NOESY), heteronuclear multiple quantum coherence (HMQC) and heteronuclear multiple bond connectivity (HMBC)) and HR-electrospray ionization (ESI)-MS analyses. The known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literature. These results can be inferred from the treatment of allergic response and inflammatory properties of Citrus medica L. var. sarcodactylis SWINGLE in traditional Chinese medicine.

原文English
頁(從 - 到)61-65
頁數5
期刊Chemical and Pharmaceutical Bulletin
58
發行號1
DOIs
出版狀態Published - 2010 一月

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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