Anti-platelet aggregation and vasorelaxing effects of the constituents of the rhizomes of zingiber officinale

Yu Ren Liao, Yann Lii Leu, Yu Yi Chan, Ping Chung Kuo, Tian Shung Wu

研究成果: Article同行評審

42 引文 斯高帕斯(Scopus)

摘要

In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol (1). Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol (13) and [6]-shogaol (17) exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol (15) inhibited the Ca 2+-dependent contractions in high K + medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism.

原文English
頁(從 - 到)8928-8937
頁數10
期刊Molecules
17
發行號8
DOIs
出版狀態Published - 2012 八月

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 化學(雜項)
  • 分子醫學
  • 藥學科學
  • 藥物發現
  • 物理與理論化學
  • 有機化學

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