Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment

Ching Hsiang Fan, Chien Yu Ting, Hao Li Liu, Chiung Yin Huang, Han Yi Hsieh, Tzu Chen Yen, Kuo Chen Wei, Chih Kuang Yeh

研究成果: Article同行評審

95 引文 斯高帕斯(Scopus)

摘要

Current chemotherapeutic agents do not only kill tumor cells but also induce systemic toxicity that significantly limits their dosage. Focused ultrasound (FUS) in the presence of microbubbles (MBs) is capable of transient and local opening of the blood-brain barrier (BBB) that enhances chemotherapeutic drug delivery into the brain parenchyma for glioma treatment. Our previous results demonstrated the success of combining the use of drug (1,3-bis(2-chloroethyl)-1-nitrosourea, BCNU)-loaded MBs with FUS-induced BBB opening to improve local drug delivery and reduce systemic toxicity. Here we introduce novel VEGF-targeting, drug-loaded MBs that significantly further enhance targeted drug release and reduce tumor progression in a rat model, using the FUS-BBB opening strategy. This study suggests a promising direction for future MB design aimed at targeted brain tumor therapy, and the possible future extension of MB application towards theragnostic use.

原文English
頁(從 - 到)2142-2155
頁數14
期刊Biomaterials
34
發行號8
DOIs
出版狀態Published - 2013 三月

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 陶瓷和複合材料
  • 生物物理學
  • 生物材料
  • 材料力學

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