@article{116e6623c55c4c918d15e860dbcf085d,
title = "Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola",
abstract = "Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC50 values of 1.81 ± 0.44 and 2.50 ± 0.64 μM, respectively. This study provides scientific insight into the nutritional supplement value and medicinal development of Fomitopsis pinicola.",
author = "Kuo, {Ping Chung} and Tai, {Shih Huang} and Hung, {Ching Che} and Hwang, {Tsong Long} and Kuo, {Liang Mou} and Lam, {Sio Hong} and Cheng, {Kun Ching} and Kuo, {Daih Huang} and Hung, {Hsin Yi} and Wu, {Tian Shung}",
note = "Funding Information: This study was sponsored by the Ministry of Science and Technology, Taiwan. Authors are thankful to Chang Gung Memorial Hospital (CMRPD1B0281~3, CMRPF1D0442~3, CMRPF 1F0011~3, CMRPF1F0061~3 and BMRP450 granted to T.-L.H.) for the partial financial support of the present study. Thanks Dr. He-Ping Chen at School of Pharmaceutical Sciences, South-Central University for Nationalities for correcting some mistakes. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = mar,
doi = "10.1016/j.bioorg.2020.104562",
language = "English",
volume = "108",
journal = "Bioorganic Chemistry",
issn = "0045-2068",
publisher = "Academic Press Inc.",
}