Antimicrobial applications of water-dispersible magnetic nanoparticles in biomedicine

Keng Shiang Huang, Dar-Bin Shieh, Chen-Sheng Yeh, Ping-Ching Wu, Fong Yu Cheng

研究成果: Article

12 引文 (Scopus)

摘要

The increasing morbidity and mortality of infectious diseases is an increasing concern. Despite the continuous development and synthesis of new antimicrobial drugs, microbial pathogens are exhibiting increased multi-drug resistance. Nanomaterials display unique and well-defined physical and chemical properties including a very high surface area to volume ratio, and new approaches for antimicrobial therapies have attempted to combine nanomaterials and current antimicrobial drugs. Magnetic nanoparticles (MNPs) are characterized by biocompatibility, biodegradation, and safety for human ingestion. Iron oxide nanoparticles have been approved for human use by the US Food and Drug Administration (FDA). For biomedicine applications, MNPs require surface modification to become water-soluble and be stable enough to resist the effects of proteins and salts in the physiological environment. MNPs can combine various substrata, such as biomolecules and nanomaterials to generate new antimicrobial agents which combine antibacterial, antiviral, and antifungal properties. This can be accomplished through a series of surface modification methods. Because MNPs have unique superparamagnetic characteristics, they can be controlled and recycled by an external magnetic field. In addition, the antimicrobial activity of MNPs-based nanocomposites is superior to that of metallic nanoparticles. This paper reviews the recent literature on the use of MNP-based nanomaterials in antimicrobial applications in biomedicine. Antimicrobial applications mainly focus on inhibiting and killing bacteria and fungi and viruses inactivation. The synthesis, surface modification, and characteristics related to MNPs will also be briefly addressed.

原文English
頁(從 - 到)3312-3322
頁數11
期刊Current Medicinal Chemistry
21
發行號29
DOIs
出版狀態Published - 2014 一月 1

指紋

Nanoparticles
Water
Nanostructures
Nanostructured materials
Surface treatment
Metal Nanoparticles
Virus Inactivation
Nanocomposites
Pharmaceutical Preparations
Multiple Drug Resistance
United States Food and Drug Administration
Magnetic Fields
Anti-Infective Agents
Biomolecules
Pathogens
Biodegradation
Fungi
Antiviral Agents
Communicable Diseases
Biocompatibility

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

引用此文

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Antimicrobial applications of water-dispersible magnetic nanoparticles in biomedicine. / Huang, Keng Shiang; Shieh, Dar-Bin; Yeh, Chen-Sheng; Wu, Ping-Ching; Cheng, Fong Yu.

於: Current Medicinal Chemistry, 卷 21, 編號 29, 01.01.2014, p. 3312-3322.

研究成果: Article

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