TY - JOUR
T1 - Antimicrobial susceptibility of bacterial pathogens associated with community-acquired respiratory tract infections in Asia
T2 - Report from the Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS) study, 2009-2010
AU - Wang, Hui
AU - Chen, Minjun
AU - Xu, Yingchun
AU - Sun, Hongli
AU - Yang, Qiwen
AU - Hu, Yunjian
AU - Cao, Bin
AU - Chu, Yunzhuo
AU - Liu, Yong
AU - Zhang, Rong
AU - Yu, Yunsong
AU - Sun, Ziyong
AU - Zhuo, Chao
AU - Ni, Yuxing
AU - Hu, Bijie
AU - Tan, Thean Yen
AU - Hsueh, Po Ren
AU - Wang, Jen Hsien
AU - Ko, Wen Chien
AU - Chen, Yen Hsu
AU - Wahjono, Hendro
N1 - Funding Information:
Funding : The CARTIPS study was funded by a grant from Bayer HealthCare Pharma .
PY - 2011/11
Y1 - 2011/11
N2 - A multicentre resistance surveillance study [Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS)] investigating the susceptibilities of 2963 clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae, meticillin-susceptible Staphylococcus aureus (MSSA) and Streptococcus spp. from Asia against 12 antimicrobial agents was undertaken from 2009 to 2010. Based on the breakpoints for oral penicillin V recommended by the Clinical and Laboratory Standards Institute, the prevalence of penicillin-non-susceptible S. pneumoniae (PNSSP) ranged from 46% to 100%. Azithromycin and clarithromycin exhibited variable resistance rates of 0-88% against S. pneumoniae, 0-57% against MSSA and 0-76.5% against Streptococcus spp. isolates. The prevalence of extended-spectrum β-lactamase-producing K. pneumoniae varied from 5.1% to 58.5%. β-Lactamase production rates amongst H. influenzae isolates ranged from 15% to 46.6% and amongst M. catarrhalis isolates from 90% to 100%. Amongst M. catarrhalis isolates, macrolide resistance and cefaclor resistance rates of 5.8% and 1.2%, respectively, were found, mainly in Mainland China. Levofloxacin resistance rates of 0-3.9% with a MIC 90 (minimum inhibitory concentration causing inhibition of 90% of isolates) of 1-2 mg/L and moxifloxacin resistance rates of 0-1.7% with a MIC 90 of 0.125-0.5 mg/L were found amongst PNSSP isolates. Moxifloxacin was very active against Streptococcus spp., H. influenzae and M. catarrhalis isolates, with MIC 90 values of 0.125-0.25, 0.032-0.5 and 0.064-0.125 mg/L, respectively. These results from the CARTIPS study have confirmed some significant regional differences in the antimicrobial susceptibilities of S. pneumoniae, MSSA, K. pneumoniae, H. influenzae and Streptococcus spp. and emphasise the importance of antimicrobial surveillance programmes for guiding empirical therapy and for focusing interventional control of antimicrobial resistance in distinct geographic areas.
AB - A multicentre resistance surveillance study [Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS)] investigating the susceptibilities of 2963 clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae, meticillin-susceptible Staphylococcus aureus (MSSA) and Streptococcus spp. from Asia against 12 antimicrobial agents was undertaken from 2009 to 2010. Based on the breakpoints for oral penicillin V recommended by the Clinical and Laboratory Standards Institute, the prevalence of penicillin-non-susceptible S. pneumoniae (PNSSP) ranged from 46% to 100%. Azithromycin and clarithromycin exhibited variable resistance rates of 0-88% against S. pneumoniae, 0-57% against MSSA and 0-76.5% against Streptococcus spp. isolates. The prevalence of extended-spectrum β-lactamase-producing K. pneumoniae varied from 5.1% to 58.5%. β-Lactamase production rates amongst H. influenzae isolates ranged from 15% to 46.6% and amongst M. catarrhalis isolates from 90% to 100%. Amongst M. catarrhalis isolates, macrolide resistance and cefaclor resistance rates of 5.8% and 1.2%, respectively, were found, mainly in Mainland China. Levofloxacin resistance rates of 0-3.9% with a MIC 90 (minimum inhibitory concentration causing inhibition of 90% of isolates) of 1-2 mg/L and moxifloxacin resistance rates of 0-1.7% with a MIC 90 of 0.125-0.5 mg/L were found amongst PNSSP isolates. Moxifloxacin was very active against Streptococcus spp., H. influenzae and M. catarrhalis isolates, with MIC 90 values of 0.125-0.25, 0.032-0.5 and 0.064-0.125 mg/L, respectively. These results from the CARTIPS study have confirmed some significant regional differences in the antimicrobial susceptibilities of S. pneumoniae, MSSA, K. pneumoniae, H. influenzae and Streptococcus spp. and emphasise the importance of antimicrobial surveillance programmes for guiding empirical therapy and for focusing interventional control of antimicrobial resistance in distinct geographic areas.
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U2 - 10.1016/j.ijantimicag.2011.06.015
DO - 10.1016/j.ijantimicag.2011.06.015
M3 - Article
C2 - 21880469
AN - SCOPUS:80053367332
SN - 0924-8579
VL - 38
SP - 376
EP - 383
JO - International journal of antimicrobial agents
JF - International journal of antimicrobial agents
IS - 5
ER -