Antiplatelet effects of protopine isolated from Corydalis tubers

Feng Nien Ko, Tian Shung Wu, Sheng Teh Lu, Yang Chang Wu, Tur Fu Huang, Che Ming Teng

研究成果: Article同行評審

26 引文 斯高帕斯(Scopus)

摘要

Protopine inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, PAF, collagen and ionophore A23187. Although the platelet aggregation caused by thrombin was not inhibited by protopine (100 ug/ml), the release reaction was partially suppressed. In rabbit platelet-rich plasma, protopine also inhibited the platelet aggregation caused by ADP, arachidonic acid, PAF and collagen. The thromboxane B2 formation of washed platelets caused by arachidonic acid, collagen, ionophore A23187 and thrombin was suppressed by protopine. Protopine inhibited the intracellular calcium increase caused by arachidonic acid in quin-2/AM loaded rabbit platelets. In the presence of indomethacin, the intracellular calcium increase caused by collagen and PAF was completely suppressed by protopine, and the intracellular calcium increase caused by thrombin was partially inhibited. The phosphoinositides breakdown caused by collagen and PAF was inhibited by protopine, but that by thrombin was not affected significantly. Protopine did not cause the elevation of cyclic AMP level of platelets. It is concluded that the antiplatelet effects of protopine is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.

原文English
頁(從 - 到)289-298
頁數10
期刊Thrombosis Research
56
發行號2
DOIs
出版狀態Published - 1989 十月 15

All Science Journal Classification (ASJC) codes

  • 血液學

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